High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients
MM Van Timmeren, VS Vaidya, RM van Ree… - …, 2007 - journals.lww.com
Background. Chronic transplant dysfunction is characterized by renal function decline and
proteinuria. Kidney injury molecule (KIM)-1, a transmembrane tubular protein with unknown …
proteinuria. Kidney injury molecule (KIM)-1, a transmembrane tubular protein with unknown …
TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells
S Nakae, M Iikura, H Suto, H Akiba… - Blood, The Journal …, 2007 - ashpublications.org
Members of the T-cell immunoglobulin–and mucin-domain–containing molecule (TIM) family
have roles in T-cell–mediated immune responses. TIM-1 and TIM-2 are predominantly …
have roles in T-cell–mediated immune responses. TIM-1 and TIM-2 are predominantly …
Structures of T Cell immunoglobulin mucin receptors 1 and 2 reveal mechanisms for regulation of immune responses by the TIM receptor family
C Santiago, A Ballesteros, C Tami, L Martínez-Muñoz… - Immunity, 2007 - cell.com
The T cell immunoglobulin mucin (TIM) receptors are involved in the regulation of immune
responses, autoimmunity, and allergy. Structures of the N-terminal ligand binding domain of …
responses, autoimmunity, and allergy. Structures of the N-terminal ligand binding domain of …
TIM-4 expressed on APCs induces T cell expansion and survival
R Rodriguez-Manzanet, JH Meyers… - The Journal of …, 2008 - journals.aai.org
TIM (T cell, Ig, mucin) proteins can regulate T cell immune responses. Tim-4 mRNA is not
expressed in T cells, but exclusively in APCs. Tim-4 is a ligand for Tim-1 and Tim-4. Ig fusion …
expressed in T cells, but exclusively in APCs. Tim-4 is a ligand for Tim-1 and Tim-4. Ig fusion …
Human TIM-1 associates with the TCR complex and up-regulates T cell activation signals
LL Binné, ML Scott, PD Rennert - The Journal of Immunology, 2007 - journals.aai.org
The T cell, Ig domain, and mucin domain-1 (TIM-1) gene is associated with Th2 T cell
responses and human atopic diseases. The mechanism by which TIM-1 influences T cell …
responses and human atopic diseases. The mechanism by which TIM-1 influences T cell …
Bimodal regulation of T cell-mediated immune responses by TIM-4
T cell Ig and mucin domain (TIM)-4 is preferentially expressed on antigen-presenting cells,
and its counter-ligand, TIM-1, is thought to deliver co-stimulating signals to T cells. However …
and its counter-ligand, TIM-1, is thought to deliver co-stimulating signals to T cells. However …
T cell Ig and mucin domain-1-mediated T cell activation requires recruitment and activation of phosphoinositide 3-kinase
AJ de Souza, JS Oak, R Jordanhazy… - The Journal of …, 2008 - journals.aai.org
Ligation of the transmembrane protein T cell Ig and mucin domain (Tim)-1 can costimulate T
cell activation. Agonistic Abs to Tim-1 are also capable of inducing T cell activation without …
cell activation. Agonistic Abs to Tim-1 are also capable of inducing T cell activation without …
Development of a novel antibody–drug conjugate for the potential treatment of ovarian, lung, and renal cell carcinoma expressing TIM-1
LJ Thomas, L Vitale, T O'Neill, RY Dolnick… - Molecular Cancer …, 2016 - AACR
T-cell immunoglobulin and mucin domain 1 (TIM-1) is a type I transmembrane protein that
was originally described as kidney injury molecule 1 (KIM-1) due to its elevated expression …
was originally described as kidney injury molecule 1 (KIM-1) due to its elevated expression …
Staphylococcal enterotoxin B increases TIM4 expression in human dendritic cells that drives naive CD4 T cells to differentiate into Th2 cells
T Liu, SH He, PY Zheng, TY Zhang, BQ Wang… - Molecular …, 2007 - Elsevier
Aberrant T helper (Th) 2 polarization plays a critical role in the pathogenesis of allergic
disorders; the etiology remains unclear. Dendritic cells (DCs) express T cell immunoglobulin …
disorders; the etiology remains unclear. Dendritic cells (DCs) express T cell immunoglobulin …
Diagnostic role of kidney injury molecule-1 in renal cell carcinoma
KJ Zhang, GD Wilson, S Kara, A Majeske… - … urology and nephrology, 2019 - Springer
Despite rapid advances in diagnostic and therapeutic medicine, renal cell carcinoma (RCC)
continues to cause significant morbidity and mortality in patients. While there has been a …
continues to cause significant morbidity and mortality in patients. While there has been a …