Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …

Ceramide accumulation is a hallmark in the manifestation of numerous obesity-related
diseases, such as type 2 diabetes mellitus and atherosclerosis. Until the early 2000s …

Ectopic lipid deposition and altered mitochondrial dynamics contribute to the development of
obesity and insulin resistance. However, the mechanistic link between these processes …

Lipid metabolism is fundamental to life. In insects, it is critical, during reproduction, flight,
starvation, and diapause. The coordination center for insect lipid metabolism is the fat body …

Triacylglycerol (TAG) is the most important caloric source with respect to energy
homeostasis in animals. In addition to its evolutionarily conserved importance as an energy …

Energy production via the mitochondrial electron transport chain (ETC) and mitophagy are
two important processes affected in Parkinson's disease (PD). Interestingly, PINK1 …

Sphingolipids have emerged as bioeffector molecules, controlling various aspects of cell
growth and proliferation in cancer, which is becoming the deadliest disease in the world …

Ceramide is located at a key hub in the sphingolipid metabolic pathway and also acts as an
important cellular signaling molecule. Ceramide contains one acyl chain which is attached …

Sphingolipids and their metabolites play key cellular roles both as structural components of
membranes and as signaling molecules that mediate responses to physiologic cues and …

Specific forms of the lipid ceramide, synthesized by the ceramide synthase enzyme family,
are believed to regulate metabolic physiology. Genetic mouse models have established C16 …