Polo-like kinase 1 (PLK1) is the principle member of the well conserved serine/threonine
kinase family. PLK1 has a key role in the progression of mitosis and recent evidence …

PP2A is a major serine/threonine phosphatase class involved in the regulation of cell
signaling through the removal of protein phosphorylation. This class of phosphatases is …

Lung adenocarcinoma (LUAD) belongs to a subgroup of non-small cell lung cancer
(NSCLC) with an increasing incidence all over the world. Tanshinone IIA (TSA), an active …

Tumour angiogenesis is an independent risk factor for bladder cancer (BCa) progression,
but viable and promising antiangiogenic targets are understudied. Secretory autophagy has …

Aurora A is a serine/threonine kinase essential for mitotic entry and spindle assembly.
Recent molecular studies have revealed the existence of multiple, distinct mechanisms of …

Abstract Aurora kinase A (Aurora-A), a serine/threonine kinase, plays a pivotal role in
various cellular processes, including mitotic entry, centrosome maturation and spindle …

Aurora kinase A (AURKA) is one of the crucial cell cycle regulators associated with gastric
cancer. Here, we explored Epstein Barr Virus-induced gastric cancer progression through …

In human cells, ATR/Chk1 signaling couples S phase exit with the expression of mitotic
inducers and prevents premature mitosis upon replication stress (RS). Nonetheless, under …

Polo-like kinase 1 (PLK1) is a serine/threonine kinase with more than 600 phosphorylation
substrates through which it regulates many biological processes, including mitosis …

Aurora-A is an essential cell-cycle kinase with critical roles in mitotic entry and spindle
dynamics. These functions require binding partners such as CEP192 and TPX2, which …