Human adenoviruses (HAdVs) are an important cause of infections in both
immunocompetent and immunocompromised individuals, and they continue to provide …

Telomeres are protective caps at the ends of human chromosomes. Telomeres shorten with
each successive cell division in normal human cells whereas, in tumors, they are …

Chronic inflammation constitutes an important link between obesity and its
pathophysiological sequelae. In contrast to the belief that inflammatory signals exert a …

Abstract Currently, 88 different Human Adenovirus (HAdV) types are grouped into seven
HAdV species A to G. Most types (57) belong to species HAdV-D. Recombination between …

The number of patients with acquired immunodeficiency has grown steadily as a result of
both a larger number of patients receiving solid organ and hematopoietic stem cell …

Replication-incompetent adenoviral vectors have been under investigation as a platform to
carry a variety of transgenes, and express them as a basis for vaccine development. A …

Human adenoviruses are the most widely used vectors in gene medicine, with applications
ranging from oncolytic therapies to vaccinations, but adenovirus vectors are not without side …

Viruses elicit cell and organismic stress, and offset homeostasis. They trigger intrinsic, innate
and adaptive immune responses, which limit infection. Viruses restore homeostasis by …

A phase I clinical trial was conducted to determine the clinical safety of Telomelysin, a
human telomerase reverse transcriptase (hTERT) promoter driven modified oncolytic …

Human adenoviruses (HAdV) are ubiquitous human pathogens that cause a significant
burden of respiratory, ocular, and gastrointestinal illnesses. Although HAdV infections are …