More than 20 syndromes among the significant and increasing number of degenerative
diseases of neuronal tissues are known to be associated with diabetes mellitus, increased …

Genetic alterations driving aberrant activation of the survival kinase Protein Kinase B (Akt)
are observed with high frequency during malignant transformation and cancer progression …

AZD0156 is a potent and selective, bioavailable inhibitor of ataxia-telangiectasia mutated
(ATM) protein, a signaling kinase involved in the DNA damage response. We present …

Purpose: To determine whether inhibition of TGFβ signaling prior to irradiation sensitizes
human and murine cancer cells in vitro and in vivo. Experimental Design: TGFβ-mediated …

Peroxisomes are highly dynamic intracellular organelles involved in a variety of metabolic
functions essential for the metabolism of long-chain fatty acids, d-amino acids, and many …

During meiotic prophase, telomeres attach to the inner nuclear envelope and cluster to form
the so-called meiotic bouquet. Although this has been observed in almost all organisms …

Abstract Marples, B., Wouters, BG, Collis, SJ, Chalmers, AJ and Joiner, MC Low-Dose Hyper-
radiosensitivity: A Consequence of Ineffective Cell Cycle Arrest of Radiation-Damaged G2 …

Nucleoside analogs are structurally, metabolically, and pharmacodynamically related
agents that nevertheless have diverse biological actions and therapeutic consequences …

Loss of DNA mismatch repair (MMR) in mammalian cells, as well as having a causative role
in cancer, has been linked to resistance to certain DNA damaging agents including clinically …

Ionizing radiation causes DNA damage that elicits a cellular program of damage control
coordinated by the kinase activity of ataxia telangiectasia mutated protein (ATM) …