The functional capabilities of skeletal muscle are strongly correlated with its well-arranged
microstructure, consisting of parallelly aligned myotubes. In case of extensive muscle loss …

Large-scale muscle injury in humans initiates a complex regeneration process, as not only
the muscular, but also the vascular and neuro-muscular compartments have to be repaired …

Atrioventricular block (AVB) is a severe disease for pediatric patients. The repetitive
operations needed in the case of the pacemaker implantation to maintain the electrical …

To regenerate functional muscle tissue, engineered scaffolds should impart topographical
features to induce myoblast alignment by a phenomenon known as contact guidance …

Cardiovascular tissue engineering is providing many solutions to cardiovascular diseases.
The complex disease demands necessitating tissue-engineered constructs with enhanced …

The topographical micro-patterning of nanofibrillar collagen gels is promising for the
fabrication of biofunctional constructs mimicking topographical cell microenvironments of in …

A great deal of research is focusing nowadays in the development of vascular substitutes to
cover the unmet clinical need of small-caliber grafts. A fundamental understanding of the …

Many tissues have a distinctly aligned microstructure which is critical for their optimal
function such as muscle tissue and vasculature. Therefore, in order to regenerate or model …

A total of 65.8 million Americans suffer from musculoskeletal injuries annually, with treatment
costs exceeding 176 billion dollars. 1-5 These injuries can cause volumetric muscle loss …