Sex hormones have been implicated in neurite outgrowth, synaptogenesis, dendritic
branching, myelination and other important mechanisms of neural plasticity. Here we review …

In response to stress, the brain activates several neuropeptide-secreting systems. This
eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed …

Signs and symptoms that are characteristic for depression include changes in the setpoint of
the hypothalamic-pituitary-adrenocortical (HPA) system, which in the majority of these …

Progesterone is commonly considered as a female reproductive hormone and is well-known
for its role in pregnancy. It is less well appreciated that progesterone and its metabolite …

Background Altered neurotransmission of γ-aminobutyric acid (GABA) has been implicated
in the pathogenesis of depression. Whether SAGE-217, an oral, positive allosteric modulator …

This chapter provides an overview of neurosteroids, especially their impact on the brain, sex
differences and their therapeutic potentials. Neurosteroids are synthesized within the brain …

Neuroactive steroids such as allopregnanolone do not only act as transcriptional factors in
the regulation of gene expression after intracellular back-oxidation into the 5-α pregnane …

The recent FDA approval of the neurosteroid, brexanolone (allopregnanolone), as a
treatment for women with postpartum depression, and successful trials of a related …

Steroids influence neuronal function by binding to intracellular receptors that can act as
transcription factors and regulate gene expression. In addition, some so-called 'neuroactive …

Progesterone is a well-known steroid hormone, synthesized by ovaries and placenta in
females, and by adrenal glands in both males and females. Several tissues are targets of …