Our populations are aging. Some experts predict that 30% of hospital beds will soon be
occupied by osteoporosis patients. Statistics show that 20% of patients suffering from an …

Polar and charged amino acids (AAs) are heavily expressed in non-collagenous proteins
(NCPs), and are involved in hydroxyapatite (HA) mineralization in bone. Here, we review …

Calcium orthophosphates are the main mineral constituents of bones and teeth, and there is
great interest in understanding the physical mechanisms that underlie their growth …

Biomineralisation is a well-regulated process mediated by extracellular matrix proteins.
Biomimetic remineralisation strategies should reproduce the dimension and structural …

The micro-architecture of nacre (mother of pearl) has been classically illustrated as a 'brick-
and-mortar'arrangement. It is clear now that hierarchical organization and other structural …

This article focuses on the relevance of amorphous calcium (and magnesium) phosphates in
living organisms. Although crystalline calcium phosphate (CaP)-based materials are known …

The polymer-controlled and bioinspired precipitation of inorganic minerals from aqueous
solution at near-ambient or physiological conditions avoiding high temperatures or organic …

Pure collagen is biocompatible but lacks inherent osteoinductive, osteoimmunomodulatory
and antibacterial activities. To obtain collagen with these characteristics, we developed a …

Biominerals exhibit complex hierarchical structures derived from bottom-up self-assembly
mechanisms. Type I collagen serves as the building block for mineralized tissues such as …

Great efforts have been made to develop potential substitutes or restorative materials for
human hard tissues such as bone and teeth. A general strategy is to mimic the functions of …