In 2007, 1179 papers were published that involved the application of optical biosensors.
Reported developments in instrument hardware, assay design, and immobilization …

Since its discovery and characterization in the early 1960s (Hurwitz, J. The discovery of RNA
polymerase. J. Biol. Chem. 2005, 280, 42477–42485), an enormous amount of biochemical …

One of the important determinants of virulence of Mycobacterium tuberculosis is adaptation
to adverse conditions encountered in the host cells. The ability of Mycobacterium to …

Responding to environmental cues is a prerequisite for survival in the microbial world.
Extracytoplasmic function σ factors (ECFs) represent the third most abundant and by far the …

Bacteria have evolved regulatory traits to rapidly adapt to changing conditions. Two principal
regulatory mechanisms to modulate gene expression consist of regulation via alternative …

Highlights•Major themes shared by ECF sigma factors are highlighted.•The mechanisms of
promoter recognition are conserved among ECF sigma factors.•Most ECF sigmas are …

Extracytoplasmic function σ factors (ECFs) represent one of the major bacterial signal
transduction mechanisms in terms of abundance, diversity and importance, particularly in …

We report a computational approach that integrates structural bioinformatics, molecular
modelling and systems biology to construct a drug-target network on a structural proteome …

Rapid adaptation to changing environments is one of the keys of the success of
microorganisms. Such adaptation is achieved by enabling different strategies, the most …

Extracytoplasmic function (ECF) sigma factors are subunits of the RNA polymerase
specialized in activating the transcription of a subset of genes responding to a specific …