AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in
the brain. Dynamic changes in neuronal synaptic efficacy, termed synaptic plasticity, are …

Long-term depression (LTD) in the CNS has been the subject of intense investigation as a
process that may be involved in learning and memory and in various pathological …

Background: The investigation of the cellular components, their interactions and related
functions constitute the major conditions in order to understand the cell as an integrated …

Protein–protein interactions within protein networks shape the human interactome, which
often is promoted by specialized protein interaction modules, such as the postsynaptic …

Targeting receptor proteins, such as ligand-gated ion channels and G protein-coupled
receptors, has directly enabled the discovery of most drugs developed to modulate receptor …

Evidence from neuropathological, genetic, animal model, and biochemical studies has
indicated that the accumulation of amyloid‐beta (Aβ) is associated with, and probably …

Peptides possess several attractive features when compared to small molecule and protein
therapeutics, such as high structural compatibility with target proteins, the ability to disrupt …

Using real-time TIRF microscopy imaging, we identify sites of clathrin and dynamin-
independent CLIC/GEEC (CG) endocytic vesicle formation. This allows spatio-temporal …

Chronic neuropathic pain is affected by specifics of the precipitating neural pathology,
psychosocial factors, and by genetic predisposition. Little is known about the identity of …

Pseudomonas aeruginosa, a Gram‐negative bacterium, is a significant opportunistic
pathogen associated with skin and soft tissue infections, nosocomial pneumonia and sepsis …