Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …

Adipose tissue, which is primarily composed of adipocytes, is crucial for maintaining energy
and metabolic homeostasis. Adipogenesis is thought to occur in two stages: commitment of …

In 1892, JL Wolff proposed that bone could respond to mechanical and biophysical stimuli
as a dynamic organ. This theory presents a unique opportunity for investigations on bone …

A diverse array of environmental factors contributes to the overall control of stem cell activity.
In particular, new data continue to mount on the influence of the extracellular matrix (ECM) …

Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with
pharmacological interventions that are associated with poor adherence and adverse effects …

Mechanobiology has underpinned many scientific advances in understanding how
biophysical and biomechanical cues regulate cell behavior by identifying mechanosensitive …

Obesity is traditionally viewed to be beneficial to bone health because of well-established
positive effect of mechanical loading conferred by body weight on bone formation, despite …

A wide range of cell types depend on mechanically induced signals to enable appropriate
physiological responses. The skeleton is particularly dependent on mechanical information …

Adult mesenchymal stem cells are a resource for autologous and allogeneic cell therapies
for immune-modulation and regenerative medicine. However, patients most in need of such …

For more than a decade, Wnt signaling pathways have been the focus of intense research
activity in bone biology laboratories because of their importance in skeletal development …