Causes of blindness differ across the globe; in higher-income countries, most blindness
results from the degeneration of specific classes of cells in the retina, including retinal …

Stem cell transplantation holds great promise as a potential treatment for currently incurable
retinal degenerative diseases that cause poor vision and blindness. Recently, safety data …

Targeted genome editing via engineered nucleases is an exciting area of biomedical
research and holds potential for clinical applications. Despite rapid advances in the field, in …

Age-related macular degeneration (AMD) is the leading cause of blindness among the
elderly in developed countries. AMD is classified as either neovascular (NV-AMD) or non …

Development of efficacious in vivo delivery platforms for CRISPR-Cas9-based epigenome
engineering will be critical to enable the ability to target human diseases without permanent …

The rapid progress in the field of stem cell research has laid strong foundations for their use
in regenerative medicine applications of injured or diseased tissues. Growing evidences …

Retinal degeneration (RD) is one of the most common causes of visual impairment and
blindness and is characterized by progressive degeneration of photoreceptors …

Purpose: To investigate whether sheets of retina organoids derived from human embryonic
stem cells (hESCs) can differentiate, integrate, and improve visual function in an …

Neurologic impairments are usually irreversible as a result of limited regeneration in the
central nervous system. Therefore, based on the regenerative capacity of stem cells …

Patient-derived induced pluripotent stem cells (iPSCs) hold great promise for autologous
cell replacement. However, for many inherited diseases, treatment will likely require genetic …