Glaucoma: the retina and beyond

BM Davis, L Crawley, M Pahlitzsch, F Javaid… - Acta …, 2016 - Springer
Over 60 million people worldwide are diagnosed with glaucomatous optic neuropathy,
which is estimated to be responsible for 8.4 million cases of irreversible blindness globally …

MR imaging of papilledema and visual pathways: effects of increased intracranial pressure and pathophysiologic mechanisms

N Passi, AJ Degnan, LM Levy - American Journal of …, 2013 - Am Soc Neuroradiology
Papilledema, defined as swelling of the optic disc, frequently occurs in the setting of
increased ICP and in a variety of medical conditions, including pseudotumor cerebri, sinus …

Advanced functional nanomaterials for theranostics

H Huang, JF Lovell - Advanced functional materials, 2017 - Wiley Online Library
Nanoscale materials have been explored extensively as agents for therapeutic and
diagnostic (ie, theranostic) applications. Research efforts have shifted from exploring new …

The cell and molecular biology of glaucoma: axonopathy and the brain

DJ Calkins, PJ Horner - Investigative ophthalmology & visual …, 2012 - iovs.arvojournals.org
Many ophthalmologists and members of the lay public alike view glaucoma in its historical
context—that is, as exclusively a disease of the eye. This view has been (and remains) …

NAP (davunetide) modifies disease progression in a mouse model of severe neurodegeneration: protection against impairments in axonal transport

Y Jouroukhin, R Ostritsky, Y Assaf, G Pelled… - Neurobiology of …, 2013 - Elsevier
NAP (davunetide) is a novel neuroprotective compound with mechanism of action that
appears to involve microtubule (MT) stabilization and repair. To evaluate, for the first time …

[HTML][HTML] Citicoline modulates glaucomatous neurodegeneration through intraocular pressure-independent control

Y van der Merwe, MC Murphy, JR Sims, MA Faiq… - …, 2021 - Elsevier
Glaucoma is a neurodegenerative disease that causes progressive, irreversible vision loss.
Currently, intraocular pressure (IOP) is the only modifiable risk factor for glaucoma …

Effect of Lycium Barbarum (Wolfberry) Polysaccharides on Preserving Retinal Function after Partial Optic Nerve Transection

PHW Chu, HY Li, MP Chin, K So, HHL Chan - PLoS One, 2013 - journals.plos.org
Lycium Barbarum Polysaccharides (LBP) are the active components of Wolfberry (a
traditional Chinese medicine) which has long been used for improving visual function. This …

Manganese-enhanced magnetic resonance imaging: overview and central nervous system applications with a focus on neurodegeneration

RA Cloyd, SA Koren, JF Abisambra - Frontiers in aging neuroscience, 2018 - frontiersin.org
Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the
1990s as a sensitive approach to high contrast imaging. Following the discovery of …

Age-related changes in eye, brain and visuomotor behavior in the DBA/2J mouse model of chronic glaucoma

XL Yang, Y Van Der Merwe, J Sims, C Parra, LC Ho… - Scientific reports, 2018 - nature.com
Although elevated intraocular pressure (IOP) and age are major risk factors for glaucoma,
their effects on glaucoma pathogenesis remain unclear. This study examined the onset and …

Effect of Lycium barbarum (Wolfberry) on Alleviating Axonal Degeneration after Partial Optic Nerve Transection

HY Li, YW Ruan, PWF Kau, K Chiu… - Cell …, 2015 - journals.sagepub.com
Our previous results showed that the polysaccharides extracted from Lycium barbarum
(LBP) could delay secondary degeneration of retinal ganglion cell bodies and improve the …