A large proportion of protein–protein interactions (PPIs) occur between a short peptide and a
globular protein domain; the peptides involved in surface interactions play important roles …

Peptide-based drug discovery has experienced a significant upturn within the past decade
since the introduction of chemical modifications and unnatural amino acids has allowed for …

The design and generation of molecules capable of mimicking the binding and/or functional
sites of proteins represents a promising strategy for the exploration and modulation of …

The HIV genome encodes a small number of viral proteins (ie, 16), invariably establishing
cooperative associations among HIV proteins and between HIV and host proteins, to invade …

The development of constrained peptides for inhibition of protein–protein interactions is an
emerging strategy in chemical biology and drug discovery. This manuscript introduces a …

Peptides and peptidomimetics can function as immunomodulating agents by either blocking
the immune response or stimulating the immune response to generate tolerance …

All-hydrocarbon stapled peptides make up a promising class of protein–protein interaction
regulators; their potential therapeutic benefit arises because they have a high binding affinity …

Beclin 1 is an essential autophagy gene and a haploinsufficient tumor suppressor. Beclin 1
is the scaffolding member of the Class III phosphatidylinositol-3-kinase complex (PI3KC3) …

In recent years the ever so complex field of drug discovery has embraced novel design
strategies based on biophysical fragment screening (fragment-based drug design; FBDD) …

Constrained α-helical peptides are an exciting class of molecule designed to disrupt protein–
protein interactions (PPIs) at a surface-exposed helix binding site. Complexes that engage …