Dysfunction of the serotonin 1A receptor (5-HT1A) may play a role in the genesis of major
depressive disorder (MDD). Here we review the pharmacological, post-mortem, positron …

Small-animal positron emission tomography (PET) is a preclinical imaging method that uses
pharmacologically or biochemically active compounds labelled with short-lived positron …

Brain serotonergic circuitries interact with other neurotransmitter systems on a multitude of
different molecular levels. In humans, as in other mammalian species, serotonin (5-HT) …

Molecular in vivo neuroimaging techniques can be used to measure regional changes in
endogenous neurotransmitters, evoked by challenges that alter synaptic neurotransmitter …

Because 5-HT1A receptors located on the soma dendrites of serotonin (5-HT) neurons
normally mediate an inhibition of 5-HT firing and release, the desensitization of these …

Neuroimaging of brain receptors began in the early 1980s. Now, some thirty-five years later,
PET imaging is still an expanding field of preclinical and clinical investigations. In addition to …

There is an increasing interest in the underlying mechanisms of the antidepressant and
anxiolytic treatment effect associated with changes in serotonergic neurotransmission after …

Serotonin (5-HT) 5-HT1A autoreceptors (5-HT1AautoR) and the plasmalemmal 5-HT
transporter (SERT) are key elements in the regulation of central 5-HT function and its …

Positron emission tomography (PET) is a molecular imaging modality that enables in vivo
exploration of metabolic processes and especially the pharmacology of neuroreceptors. G …

The pathogenesis of amyotrophic lateral sclerosis (ALS) remains obscure, but it is now clear
that neuronal loss is not confined to the motor cortex, even in cases without dementia. A …