5-HT1A receptor function in major depressive disorder
J Savitz, I Lucki, WC Drevets - Progress in neurobiology, 2009 - Elsevier
Dysfunction of the serotonin 1A receptor (5-HT1A) may play a role in the genesis of major
depressive disorder (MDD). Here we review the pharmacological, post-mortem, positron …
depressive disorder (MDD). Here we review the pharmacological, post-mortem, positron …
Small-animal positron emission tomography as a tool for neuropharmacology
S Lancelot, L Zimmer - Trends in pharmacological sciences, 2010 - cell.com
Small-animal positron emission tomography (PET) is a preclinical imaging method that uses
pharmacologically or biochemically active compounds labelled with short-lived positron …
pharmacologically or biochemically active compounds labelled with short-lived positron …
Brain serotonergic circuitries
Y Charnay, L Léger - Dialogues in clinical neuroscience, 2010 - Taylor & Francis
Brain serotonergic circuitries interact with other neurotransmitter systems on a multitude of
different molecular levels. In humans, as in other mammalian species, serotonin (5-HT) …
different molecular levels. In humans, as in other mammalian species, serotonin (5-HT) …
Measuring endogenous 5-HT release by emission tomography: promises and pitfalls
LM Paterson, RJ Tyacke, DJ Nutt… - Journal of Cerebral …, 2010 - journals.sagepub.com
Molecular in vivo neuroimaging techniques can be used to measure regional changes in
endogenous neurotransmitters, evoked by challenges that alter synaptic neurotransmitter …
endogenous neurotransmitters, evoked by challenges that alter synaptic neurotransmitter …
Acute treatment with the antidepressant fluoxetine internalizes 5-HT1A autoreceptors and reduces the in vivo binding of the PET radioligand [18F] MPPF in the …
Because 5-HT1A receptors located on the soma dendrites of serotonin (5-HT) neurons
normally mediate an inhibition of 5-HT firing and release, the desensitization of these …
normally mediate an inhibition of 5-HT firing and release, the desensitization of these …
PET radiotracers for molecular imaging in the brain: past, present and future
L Zimmer, A Luxen - Neuroimage, 2012 - Elsevier
Neuroimaging of brain receptors began in the early 1980s. Now, some thirty-five years later,
PET imaging is still an expanding field of preclinical and clinical investigations. In addition to …
PET imaging is still an expanding field of preclinical and clinical investigations. In addition to …
Influence of escitalopram treatment on 5-HT1A receptor binding in limbic regions in patients with anxiety disorders
C Spindelegger, R Lanzenberger, W Wadsak… - Molecular …, 2009 - nature.com
There is an increasing interest in the underlying mechanisms of the antidepressant and
anxiolytic treatment effect associated with changes in serotonergic neurotransmission after …
anxiolytic treatment effect associated with changes in serotonergic neurotransmission after …
Effects of the antidepressant fluoxetine on the subcellular localization of 5-HT1A receptors and SERT
L Descarries, M Riad - … of the Royal Society B: Biological …, 2012 - royalsocietypublishing.org
Serotonin (5-HT) 5-HT1A autoreceptors (5-HT1AautoR) and the plasmalemmal 5-HT
transporter (SERT) are key elements in the regulation of central 5-HT function and its …
transporter (SERT) are key elements in the regulation of central 5-HT function and its …
Is there a role for GPCR agonist radiotracers in PET neuroimaging?
Positron emission tomography (PET) is a molecular imaging modality that enables in vivo
exploration of metabolic processes and especially the pharmacology of neuroreceptors. G …
exploration of metabolic processes and especially the pharmacology of neuroreceptors. G …
[11C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS
The pathogenesis of amyotrophic lateral sclerosis (ALS) remains obscure, but it is now clear
that neuronal loss is not confined to the motor cortex, even in cases without dementia. A …
that neuronal loss is not confined to the motor cortex, even in cases without dementia. A …