Regulation of insulin secretion by the post-translational modifications
C Yang, M Wei, Y Zhao, Z Yang, M Song… - Frontiers in Cell and …, 2023 - frontiersin.org
Post-translational modification (PTM) has a significant impact on cellular signaling and
function regulation. In pancreatic β cells, PTMs are involved in insulin secretion, cell …
function regulation. In pancreatic β cells, PTMs are involved in insulin secretion, cell …
Roles and regulation of the transcription factor CREB in pancreatic β-cells
S Dalle, J Quoyer, E Varin… - Current molecular …, 2011 - ingentaconnect.com
The preservation of a functional pancreatic β-cell mass has become a major point of
research in type 2 diabetes (T2D) and the future therapies of T2D notably aim at protecting …
research in type 2 diabetes (T2D) and the future therapies of T2D notably aim at protecting …
WISP1, a pro-mitogenic, pro-survival factor, mediates tumor necrosis factor-α (TNF-α)-stimulated cardiac fibroblast proliferation but inhibits TNF-α-induced …
K Venkatachalam, B Venkatesan, AJ Valente… - Journal of Biological …, 2009 - ASBMB
WNT1-inducible signaling pathway protein-1 (WISP1), a member of the CYR61/CTGF/Nov
family of growth factors, can mediate cell growth, transformation, and survival. Previously we …
family of growth factors, can mediate cell growth, transformation, and survival. Previously we …
Paired box 6 programs essential exocytotic genes in the regulation of glucose-stimulated insulin secretion and glucose homeostasis
The paired box 6 (PAX6) transcription factor is crucial for normal pancreatic islet
development and function. Heterozygous mutations of PAX6 are associated with impaired …
development and function. Heterozygous mutations of PAX6 are associated with impaired …
Stimulation of the hippocampal POMC/MC4R circuit alleviates synaptic plasticity impairment in an Alzheimer's disease model
Hippocampal synaptic plasticity is modulated by neuropeptides, the disruption of which
might contribute to cognitive deficits observed in Alzheimer's disease (AD). Although pro …
might contribute to cognitive deficits observed in Alzheimer's disease (AD). Although pro …
Exendin-4 protects pancreatic beta cells from palmitate-induced apoptosis by interfering with GPR40 and the MKK4/7 stress kinase signalling pathway
A Natalicchio, R Labarbuta, F Tortosa, G Biondi… - Diabetologia, 2013 - Springer
Aims/hypothesis The mechanisms of the protective effects of exendin-4 on NEFA-induced
beta cell apoptosis were investigated. Methods The effects of exendin-4 and palmitate were …
beta cell apoptosis were investigated. Methods The effects of exendin-4 and palmitate were …
[HTML][HTML] CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells
Abstract Objective Glucagon-like peptide-1 (GLP-1) plays a major role in pancreatic β-cell
function and survival by increasing cytoplasmic cAMP levels, which are thought to affect …
function and survival by increasing cytoplasmic cAMP levels, which are thought to affect …
Preservation of β-cell function by targeting β-cell mass
EJP de Koning, S Bonner-Weir, TJ Rabelink - Trends in pharmacological …, 2008 - cell.com
Type 2 diabetes is characterized by progressive β-cell dysfunction and a reduction in β-cell
mass. Pancreatic islets are a target for adverse effectors such as high concentrations of …
mass. Pancreatic islets are a target for adverse effectors such as high concentrations of …
Gastrointestinal hormones and the regulation of β‐cell mass
Type 2 diabetes occurs due to a relative deficit in β‐cell mass or function. Glucagon‐like
peptide 1 (GLP‐1), glucose‐dependent insulinotropic polypeptide (GIP), cholecystokinin …
peptide 1 (GLP‐1), glucose‐dependent insulinotropic polypeptide (GIP), cholecystokinin …
Exendin-4 prevents c-Jun N-terminal protein kinase activation by tumor necrosis factor-α (TNFα) and inhibits TNFα-induced apoptosis in insulin-secreting cells
A Natalicchio, F De Stefano, MR Orlando… - …, 2010 - academic.oup.com
Glucagon-like peptide-1 and its analogs may preserve pancreatic β-cell mass by promoting
resistance to cytokine-mediated apoptosis. The mechanisms of TNFα-induced apoptosis …
resistance to cytokine-mediated apoptosis. The mechanisms of TNFα-induced apoptosis …