α-Synuclein misfolding and aggregation: Implications in Parkinson's disease pathogenesis
Abstract α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …
Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson's disease
Parkinson's disease (PD) is a complex, chronic and progressive neurodegenerative
disease. While the etiology of PD is likely multifactorial, the protein α-synuclein is a central …
disease. While the etiology of PD is likely multifactorial, the protein α-synuclein is a central …
Cryo-EM structure of alpha-synuclein fibrils
Parkinson's disease is a progressive neuropathological disorder that belongs to the class of
synucleinopathies, in which the protein alpha-synuclein is found at abnormally high …
synucleinopathies, in which the protein alpha-synuclein is found at abnormally high …
Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease
LMA Oliveira, T Gasser, R Edwards… - npj Parkinson's …, 2021 - nature.com
With the advent of the genetic era in Parkinson's disease (PD) research in 1997, α-synuclein
was identified as an important player in a complex neurodegenerative disease that affects> …
was identified as an important player in a complex neurodegenerative disease that affects> …
α‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities
P Alam, L Bousset, R Melki… - Journal of …, 2019 - Wiley Online Library
This review article provides an overview of the different species that α‐synuclein aggregates
can populate. It also attempts to reconcile conflicting views regarding the cytotoxic roles of …
can populate. It also attempts to reconcile conflicting views regarding the cytotoxic roles of …
Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy
Intracellular inclusions rich in alpha-synuclein are a hallmark of several neuropathological
diseases including Parkinson's disease (PD). Previously, we reported the structure of alpha …
diseases including Parkinson's disease (PD). Previously, we reported the structure of alpha …
Liquid-liquid phase separation of α-synuclein: a new mechanistic insight for α-synuclein aggregation associated with Parkinson's disease pathogenesis
Aberrant aggregation of the misfolded presynaptic protein, α-Synuclein (α-Syn) into Lewy
body (LB) and Lewy neuritis (LN) is a major pathological hallmark of Parkinson's disease …
body (LB) and Lewy neuritis (LN) is a major pathological hallmark of Parkinson's disease …
The synaptic function of α-synuclein
J Burré - Journal of Parkinson's disease, 2015 - content.iospress.com
Abstract α-Synuclein is an abundant neuronal protein which localizes predominantly to
presynaptic terminals, and is strongly linked genetically and pathologically to Parkinson's …
presynaptic terminals, and is strongly linked genetically and pathologically to Parkinson's …
The many faces of α-synuclein: from structure and toxicity to therapeutic target
HA Lashuel, CR Overk, A Oueslati… - Nature Reviews …, 2013 - nature.com
Disorders characterized by α-synuclein (α-syn) accumulation, Lewy body formation and
parkinsonism (and in some cases dementia) are collectively known as Lewy body diseases …
parkinsonism (and in some cases dementia) are collectively known as Lewy body diseases …
Chaperone-mediated autophagy: roles in disease and aging
AM Cuervo, E Wong - Cell research, 2014 - nature.com
This review focuses on chaperone-mediated autophagy (CMA), one of the proteolytic
systems that contributes to degradation of intracellular proteins in lysosomes. CMA substrate …
systems that contributes to degradation of intracellular proteins in lysosomes. CMA substrate …