The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions

TJ Littlejohns, J Holliday, LM Gibson, S Garratt… - Nature …, 2020 - nature.com
UK Biobank is a population-based cohort of half a million participants aged 40–69 years
recruited between 2006 and 2010. In 2014, UK Biobank started the world's largest multi …

Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies

N Stefan, HU Häring, K Cusi - The lancet Diabetes & endocrinology, 2019 - thelancet.com
The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. In
some patients with NAFLD, isolated steatosis can progress to advanced stages with non …

Breakthroughs in therapies for NASH and remaining challenges

V Ratziu, S Francque, A Sanyal - Journal of hepatology, 2022 - Elsevier
Initially a condition that received limited recognition and whose clinical impact was
controversial, non-alcoholic steatohepatitis (NASH) has become a leading cause of chronic …

Noninvasive biomarkers in NAFLD and NASH—current progress and future promise

VWS Wong, LA Adams, V de Lédinghen… - Nature reviews …, 2018 - nature.com
Nonalcoholic fatty liver disease (NAFLD) affects 25% of the global adult population and is
the most common chronic liver disease worldwide. Nonalcoholic steatohepatitis (NASH) is …

Noninvasive Diagnosis of NAFLD and NASH

VA Piazzolla, A Mangia - Cells, 2020 - mdpi.com
The aim of this review is to outline emerging biomarkers that can serve as early diagnostic
tools to identify patients with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic …

Non-invasive evaluation of response to obeticholic acid in patients with NASH: Results from the REGENERATE study

ME Rinella, JF Dufour, QM Anstee, Z Goodman… - Journal of …, 2022 - Elsevier
Background & Aims Non-alcoholic steatohepatitis (NASH) is a chronic, progressive fibrotic
liver disease that can lead to cirrhosis. While liver biopsy is considered the reference …

Pathobiology of liver fibrosis: a translational success story

YA Lee, MC Wallace, SL Friedman - Gut, 2015 - gut.bmj.com
Reversibility of hepatic fibrosis and cirrhosis following antiviral therapy for hepatitis B or C
has advanced the prospect of developing antifibrotic therapies for patients with chronic liver …

[HTML][HTML] Hepatic fibrosis: concept to treatment

C Trautwein, SL Friedman, D Schuppan, M Pinzani - Journal of hepatology, 2015 - Elsevier
Understanding the molecular mechanisms underlying liver fibrogenesis is fundamentally
relevant to developing new treatments that are independent of the underlying etiology. The …

Nonalcoholic fatty liver disease: pathogenesis and disease spectrum

T Hardy, F Oakley, QM Anstee… - Annual review of …, 2016 - annualreviews.org
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver dysfunction in
the Western world and is increasing owing to its close association with obesity and insulin …

[HTML][HTML] Noninvasive evaluation of nonalcoholic fatty liver disease: Current evidence and practice

JH Zhou, JJ Cai, ZG She, HL Li - World journal of gastroenterology, 2019 - ncbi.nlm.nih.gov
With the increasing number of individuals with diabetes and obesity, nonalcoholic fatty liver
disease (NAFLD) is becoming increasingly prevalent, affecting one-quarter of adults …