Highlights•Next generation sequencing technologies have enabled large-scale genome
analyses.•Pan-genome analyses provide a framework for predicting and modeling genomic …

Bacterial genomes evolve through mutations, rearrangements or horizontal gene transfer.
Besides the core genes encoding essential metabolic functions, bacterial genomes also …

Recent advances in ultra-high-throughput sequencing technology and metagenomics have
led to a paradigm shift in microbial genomics from few genome comparisons to large-scale …

Antibiotic resistance is a serious global threat for public health. Considering the high
abundance of cell-free DNA encoding antibiotic resistance genes (ARGs) in both clinical …

Background Multiple genome alignment remains a challenging problem. Effects of
recombination including rearrangement, segmental duplication, gain, and loss can create a …

Genomes at the species level are dynamic, with genes present in every individual (core) and
genes in a subset of individuals (dispensable) that collectively constitute the pan-genome …

Leptospirosis, caused by spirochetes of the genus Leptospira, is a globally widespread,
neglected and emerging zoonotic disease. While whole genome analysis of individual …

With the rapid development of DNA sequencing technology, increasing bacteria genome
data enable the biologists to dig the evolutionary and genetic information of prokaryotic …

Uncovers the Key Role Microbes Play in the Transformation of Oxidizable and Reducible
MineralsMany areas of geomicrobial processes are receiving serious attention from …

Bacterial genome sequencing has become so easy and accessible that the genomes of
multiple strains of more and more individual species have been and will be generated …