Synaptic plasticity is a key component of the learning machinery in the brain. It is vital that
such plasticity be tightly regulated so that it occurs to the proper extent at the proper time …

Modern theories of memory storage have largely focused on persistent, experience-
dependent changes in synaptic function such as long-term potentiation and depression. But …

Long-term potentiation and long-term depression are enduring changes in synaptic strength,
induced by specific patterns of synaptic activity, that have received much attention as cellular …

Glutamate receptors are the most abundant excitatory neurotransmitter receptors in the
brain, responsible for mediating the vast majority of excitatory transmission in neuronal …

The activation of cAMP-response element binding protein (CREB)-dependent gene
expression seems a crucial step in the molecular cascade that mediates the formation of …

Spatio-temporal configurations of distributed activity in the brain is thought to contribute to
the coding of neuronal information and synaptic contacts between nerve cells could play a …

Memory is supported by a specific collection of neurons distributed in broad brain areas, an
engram. Despite recent advances in identifying an engram, how the engram is created …

Calcium-activated potassium channels are a large family of potassium channels that are
found throughout the central nervous system and in many other cell types. These channels …

The input–output relationship of neuronal networks depends both on their synaptic
connectivity and on the intrinsic properties of their neuronal elements. In addition to altered …

Synaptic plasticity in the mammalian central nervous system has been the subject of intense
investigation for the past four decades. Long-term potentiation (LTP), a major reflection of …