Peroxisome proliferator–activated receptor α (PPAR α) is a nuclear receptor of clinical
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription
factors that are involved in regulating glucose and lipid homeostasis, inflammation …

In addition to oxidative phosphorylation (OXPHOS), mitochondria perform other functions
such as heme biosynthesis and oxygen sensing and mediate calcium homeostasis, cell …

Every year almost 500,000 new patients are diagnosed with hepatocellular carcinoma
(HCC), a primary malignancy of the liver that is associated with a poor prognosis. Numerous …

The peroxisome proliferator-activated receptor α (PPARα, or NR1C1) is a nuclear hormone
receptor activated by a structurally diverse array of synthetic chemicals known as …

Several therapeutic agents and industrial chemicals induce liver tumors in rodents through
the activation of the peroxisome proliferator-activated receptor alpha (PPARα). The cellular …

Background Concern over phthalates has emerged because of their potential toxicity to
humans. Objective We investigated the relationship between the urinary concentrations of …

A number of industrial chemicals and therapeutic agents cause liver tumors in rats and mice
by activating the nuclear receptor peroxisome proliferator-activated receptor α (PPARα). The …

Peroxisome proliferator‐activated receptors (PPARs) are ligand‐activated transcription
factors that belong to the nuclear hormone receptor superfamily. PPARα is mainly expressed …

Because of their wide range of actions on glucose homeostasis, lipid metabolism and
vascular inflammation, peroxisome proliferator-activated receptors (PPARs) are promising …