Adenomatous polyposis coli (APC) is widely accepted as a tumor suppressor gene highly
mutated in colorectal cancers (CRC). Mutation and inactivation of this gene is a key and …

The Wnt/β-catenin pathway is highly regulated to insure the correct temporal and spatial
activation of its target genes. In the absence of a Wnt stimulus, the transcriptional coactivator …

Directed cell migration is critical for embryogenesis and organ development, wound healing
and the immune response. Microtubules are dynamic polymers that control directional …

Eukaryotic cells create internal order by using protein motors to transport molecules and
organelles along cytoskeletal tracks. Recent genomic and functional studies suggest that …

Wnt signaling transduces evolutionarily conserved pathways which play important roles in
initiating and regulating a diverse range of cellular activities, including cell proliferation …

Life implies movement. Most forms of movement in the living world are powered by tiny
protein machines known as molecular motors. Among the best known are motors that use …

Rho GTPases control signal transduction pathways that link cell surface receptors to a
variety of intracellular responses. They are best known as regulators of the actin …

Abstract Glycogen synthase kinase-3 (GSK3) is now recognized as a key component of a
surprisingly large number of cellular processes and diseases. Several mechanisms play a …

The Wnt signaling pathway, named for its most upstream ligands, the Wnts, is involved in
various differentiation events during embryonic development and leads to tumor formation …

Microtubule plus-end tracking proteins (+ TIPs) are a diverse group of evolutionarily
conserved cellular factors that accumulate at the ends of growing microtubules. They form …