Recombinant protein vaccines, a proven approach against coronavirus pandemics

J Pollet, WH Chen, U Strych - Advanced drug delivery reviews, 2021 - Elsevier
With the COVID-19 pandemic now ongoing for close to a year, people all over the world are
still waiting for a vaccine to become available. The initial focus of accelerated global …

Twenty-five-year research progress in hookworm excretory/secretory products

AMI Abuzeid, X Zhou, Y Huang, G Li - Parasites & vectors, 2020 - Springer
Hookworm infection is a major public health problem that threatens about 500 million people
throughout tropical areas of the world. Adult hookworms survive for many years in the host …

Schistosomiasis and hookworm infection in humans: Disease burden, pathobiology and anthelmintic vaccines

N Tsuji - Parasitology international, 2020 - Elsevier
Helminth diseases are the ancient scourges of humans and their damages are 'silent and
insidious'. Of the helminth infections, schistosomiasis and hookworm infection have a great …

Molecular modification and biotechnological applications of microbial aspartic proteases

RA Herman, E Ayepa, WX Zhang, ZN Li… - Critical Reviews in …, 2024 - Taylor & Francis
The growing preference for incorporating microbial aspartic proteases in industries is due to
their high catalytic function and high degree of substrate selectivity. These properties …

Safety and immunogenicity of co-administered hookworm vaccine candidates Na-GST-1 and Na-APR-1 in Gabonese adults: a randomised, controlled, double-blind …

AA Adegnika, SG de Vries, FJ Zinsou… - The Lancet Infectious …, 2021 - thelancet.com
Background Hookworms cause substantial morbidity in children and women of reproductive
age. The control strategy of mass drug administration is suboptimal, hence the need for a …

[HTML][HTML] Vaccine value profile for Hookworm

KP Puchner, ME Bottazzi, V Periago, M Grobusch… - vaccine, 2024 - Elsevier
Hookworm, a parasitic infection, retains a considerable burden of disease, affecting the most
underprivileged segments of the general population in endemic countries and remains one …

Human anthelminthic vaccines: Rationale and challenges

PJ Hotez, U Strych, S Lustigman, ME Bottazzi - Vaccine, 2016 - Elsevier
Helminth infections are the most common afflictions of humankind, affecting almost every
single person living in profound poverty. Through mass drug administration (MDA) we have …

Oral peptide vaccine against hookworm infection: correlation of antibody titers with protective efficacy

AO Shalash, L Becker, J Yang, P Giacomin, M Pearson… - Vaccines, 2021 - mdpi.com
Approximately 0.4 billion individuals worldwide are infected with hookworm. An effective
vaccine is needed to not only improve the health of those affected and at high risk, but also …

Of dogs and hookworms: man's best friend and his parasites as a model for translational biomedical research

C Shepherd, P Wangchuk, A Loukas - Parasites & vectors, 2018 - Springer
We present evidence that the dog hookworm (Ancylostoma caninum) is underutilised in the
study of host-parasite interactions, particularly as a proxy for the human-hookworm …

Modeling the economic and epidemiologic impact of hookworm vaccine and mass drug administration (MDA) in Brazil, a high transmission setting

SM Bartsch, PJ Hotez, DL Hertenstein, DJ Diemert… - Vaccine, 2016 - Elsevier
Background Although mass drug administration (MDA) has helped reduce morbidity
attributed to soil-transmitted helminth infections in children, its limitations for hookworm …