A multitude of evidence has suggested the differential incidence, prevalence and severity of
asthma between males and females. A compilation of recent literature recognized sex …

Sex-steroid signaling, especially estrogen, has a paradoxical impact on regulating airway
remodeling. In our previous studies, we demonstrated differential effects of 17β-estradiol (E …

Asthma is a multifactorial disease of origin characterized by airway hyperresponsiveness
(AHR) and airway remodeling. Several pieces of evidence from other pathologies suggest …

Airway-associated adipose tissue increases with body mass index and is a local source of
pro-inflammatory adipokines that may contribute to airway pathology in asthma co-existing …

Airway remodeling is a cardinal feature of asthma, associated with increased airway smooth
muscle (ASM) cell mass and upregulation of extracellular matrix deposition. Exaggerated …

Airway smooth muscle cell (ASM) is renowned for its involvement in airway
hyperresponsiveness through impaired ASM relaxation and bronchoconstriction in asthma …

© Annals of Translational Medicine. All rights reserved. Ann Transl Med 2022; 10 (20): 1084|
https://dx. doi. org/10.21037/atm-22-4478 increased proliferation in vitro. Similarly, the …

Asthma is characterized by airway hyperresponsiveness, airway remodeling (structural
changes), and airway inflammation. Although current medications can mitigate airway …

Патология органов дыхания является ведущей в структуре общей заболеваемости
человека. С каждым годом число заболеваний дыхательной системы возрастает …

Asthma is a chronic respiratory disorder that affects people of all ages. Sex and gender
disparity in asthma is recognized and suggests a modulatory role for sex steroids …