Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation. Since
flow is the result of a driving pressure that promotes flow and of an opposing resistance that …

Chronic hypoxia induces pulmonary vascular remodeling, leading to pulmonary
hypertension, right ventricular hypertrophy, and heart failure. Heterozygous deficiency of …

The therapeutic potential of stem cells in chronic obstructive pulmonary disease is not well
known although stem cell therapy is effective in models of other pulmonary diseases. We …

In the pulmonary artery isolated from 1-week hypoxia-induced pulmonary hypertensive rats,
endothelial NO production stimulated by carbachol was decreased significantly in in situ …

Despite being the most common respiratory disorder in the developed world and the fourth
leading cause of death in the US, chronic obstructive pulmonary disease (COPD) has …

The arteriovenous (AV) fistula is the access method of choice for long-term hemodialysis
according to DOQI guidelines. Among the recognized complications of upper extremity AV …

Structural changes of the pulmonary circulation during the pathogenesis of pulmonary
arterial hypertension remain to be fully elucidated. Although angiography has been used for …

Chronic exposure to hypoxia, a common adverse consequence of most pulmonary
disorders, can lead to a sustained increase in pulmonary arterial pressure (PAP), right …

Background There are studies reporting that uric acid elevation is a marker for hypoxemia
and pulmonary hypertension secondary to some diseases. Aim The aim of this study is to …

Hypoxia down-regulates the expression of the growth arrest–specific homeobox (Gax) in
pulmonary arterial smooth muscle cells (PASMCs), resulting in increased cell proliferation …