[HTML][HTML] Tertiary lymphoid structures in diseases: immune mechanisms and therapeutic advances

L Zhao, S Jin, S Wang, Z Zhang, X Wang… - … and Targeted Therapy, 2024 - nature.com
Tertiary lymphoid structures (TLSs) are defined as lymphoid aggregates formed in non-
hematopoietic organs under pathological conditions. Similar to secondary lymphoid organs …

[HTML][HTML] Immunotherapy with immune checkpoint inhibitors and predictive biomarkers in malignant mesothelioma: work still in progress

M Perrino, F De Vincenzo, N Cordua, F Borea… - Frontiers in …, 2023 - frontiersin.org
Malignant mesothelioma (MM) is a rare and aggressive neoplasm, usually associated with a
poor prognosis (5 years survival rate< 10%). For unresectable disease, platinum and …

Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma

B Giotti, K Dolasia, W Zhao, P Cai, R Sweeney… - Cancer …, 2024 - aacrjournals.org
Immunotherapies have shown great promise in pleural mesothelioma (PM), yet most
patients still do not achieve significant clinical response, highlighting the importance of …

[HTML][HTML] Benefits and challenges of inhibiting EZH2 in malignant pleural mesothelioma

MHDO Al Khatib, G Pinton, L Moro, C Porta - Cancers, 2023 - mdpi.com
Simple Summary Malignant pleural mesothelioma (MPM) is an aggressive cancer linked to
asbestos exposure with an extremely poor outcome. Despite the recent approval of immune …

[HTML][HTML] Immunotherapy of mesothelioma: the evolving change of a long-standing therapeutic dream

L Calabrò, G Bronte, F Grosso, L Cerbone… - Frontiers in …, 2024 - frontiersin.org
Pleural mesothelioma (PM) is an aggressive and rare disease, characterized by a very poor
prognosis. For almost two decades, the world standard treatment regimen for unresectable …

[HTML][HTML] Genomic Landscape of Pleural Mesothelioma and Therapeutic Aftermaths

A Nash, J Creaney - Current oncology reports, 2023 - Springer
Abstract Purpose of Review In this article, we provide a comprehensive analysis of recent
progress in the genetic characterisation of pleural mesothelioma, and the translation of …

[HTML][HTML] The Italian experience in the development of mesothelioma registries: a pathway for other countries to address the negative legacy of asbestos

C Magnani, C Mensi, A Binazzi, D Marsili… - International Journal of …, 2023 - mdpi.com
Asbestos (all forms, including chrysotile, crocidolite, amosite, tremolite, actinolite, and
anthophyllite) is carcinogenic to humans and causally associated with mesothelioma and …

[HTML][HTML] Tumor treating fields affect mesothelioma cell proliferation by exerting histotype-dependent cell cycle checkpoint activations and transcriptional modulations

L Mannarino, F Mirimao, N Panini, L Paracchini… - Cell Death & …, 2022 - nature.com
Although clinical antitumor activity of Tumor Treating Fields (TTFields) has been reported in
malignant pleural mesothelioma (MPM) patients, the mechanisms behind the different …

[HTML][HTML] Tertiary Lymphoid Structures in Microorganism-Related Cancer

S Deng, X Yang, L He, Y Hou, H Meng - Cancers, 2024 - mdpi.com
Simple Summary The role of tertiary lymphoid structures (TLSs) in cancer has been
extensively studied, including predicting good prognosis and immunotherapy efficacy …

[HTML][HTML] Current State-of-the-Art Therapy for Malignant Pleural Mesothelioma and Future Options Centered on Immunotherapy

S Cedres, A Valdivia, P Iranzo, A Callejo, N Pardo… - Cancers, 2023 - mdpi.com
Simple Summary Advances in malignant pleural mesothelioma research have led to the
approval of first-line immunotherapies and the development of numerous trials of new first …