Dynamic localization of receptors and signaling molecules at the plasma membrane and
within intracellular vesicular compartments is crucial for T lymphocyte sensing …

Human immunodeficiency virus (HIV) infection, despite great advances in antiretroviral
therapy, remains a lifelong affliction. Though current treatment regimens can effectively …

Abstract Programmed death ligand-1 (PD-L1) and indoleamine 2, 3-dioxygenase 1 (IDO1)
are immune checkpoints induced by interferon-γ (IFN-γ) in the tumor microenvironment …

The identification of exclusive markers to target HIV-reservoir cells will represent a
significant advance in the search for therapies to cure HIV. Here, we identify the B …

HIV-1 encodes four accesory proteins in addition to its structural and regulatory genes.
Uniquely amongst them, Vpr is abundantly present within virions, meaning it is poised to …

Akt signaling plays a central role in many biological processes, which are key players in
human immunodeficiency virus 1 (HIV-1) pathogenesis. We found that Akt interacts with HIV …

Host and viral factors influence the HIV-1 infection course. Reduced Nef function has been
observed in HIV-1 controllers during the chronic phase, but the kinetics and mechanisms of …

It has recently emerged that HIV-1 Nef counteracts the antiviral host proteins SERINC3 and
SERINC5. In particular, SERINC5 inhibits the infectivity of progeny virions when …

Endosomal traffic of TCR and signaling molecules regulates immunological synapse
formation and T cell activation. We recently showed that Rab11 endosomes regulate the …

Introduction Current medications for autoimmune disorders often induce broad-ranging side
effects, prompting a growing interest in therapies with more specific immune system …