Molecular pathways of major depressive disorder converge on the synapse

GR Fries, VA Saldana, J Finnstein, T Rein - Molecular Psychiatry, 2023 - nature.com
Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …

[HTML][HTML] Polyphenols inhibiting MAPK signalling pathway mediated oxidative stress and inflammation in depression

T Behl, T Rana, GH Alotaibi, M Shamsuzzaman… - Biomedicine & …, 2022 - Elsevier
Depression is one of the most debilitating psychiatric disorders affecting people of all ages
worldwide. Despite significant heterogeneity between studies, increased inflammation and …

Peripheral markers of depression

A Nobis, D Zalewski, N Waszkiewicz - Journal of clinical medicine, 2020 - mdpi.com
Major Depressive Disorder (MDD) is a leading cause of disability worldwide, creating a high
medical and socioeconomic burden. There is a growing interest in the biological …

Environmental noiseinduced effects on stress hormones, oxidative stress, and vascular dysfunction: Key factors in the relationship between cerebrocardiovascular …

O Hahad, JH Prochaska, A Daiber… - Oxidative medicine and …, 2019 - Wiley Online Library
The role of noise as an environmental pollutant and its adverse effects on health are being
increasingly recognized. Beyond its direct effects on the auditory system (eg, hearing loss …

Oxidative stress, inflammation and treatment response in major depression

D Lindqvist, FS Dhabhar, SJ James, CM Hough… - …, 2017 - Elsevier
Objective Increased inflammation and oxidative stress have been shown in Major
Depressive Disorder (MDD), although there is significant heterogeneity across studies …

Selecting an appropriate animal model of depression

Y Hao, H Ge, M Sun, Y Gao - International journal of molecular sciences, 2019 - mdpi.com
Depression has become one of the most severe psychiatric disorders and endangers the
health of living beings all over the world. In order to explore the molecular mechanism that …

Free radicals and oxidative stress: Signaling mechanisms, redox basis for human diseases, and cell cycle regulation

IZ Sadiq - Current Molecular Medicine, 2023 - benthamdirect.com
Free radicals contain one or more unpaired electrons in their valence shell, thus making
them unstable, short-lived, and highly reactive species. Excessive generation of these free …

Depression and its phytopharmacotherapy—a narrative review

L Dobrek, K Głowacka - International Journal of Molecular Sciences, 2023 - mdpi.com
Depression is a mental health disorder that develops as a result of complex psycho-neuro-
immuno-endocrinological disturbances. This disease presents with mood disturbances …

Cytokines, oxidative stress and cellular markers of inflammation in schizophrenia

R Upthegrove, GM Khandaker - Neuroinflammation and schizophrenia, 2020 - Springer
In this article, we review current evidence linking immune dysfunction in schizophrenia and
related psychotic disorders focusing particularly on circulating cytokines, oxidative stress …

Bipolar disorder and immune dysfunction: epidemiological findings, proposed pathophysiology and clinical implications

JD Rosenblat, RS McIntyre - Brain sciences, 2017 - mdpi.com
Bipolar disorder (BD) is strongly associated with immune dysfunction. Replicated
epidemiological studies have demonstrated that BD has high rates of inflammatory medical …