Two principal theories for the pathogenesis of glaucomatous optic neuropathy (GON) have
been described—a mechanical and a vascular theory. Both have been defended by various …

While a pathway for Ca2+ accumulation into mitochondria has long been established, its
functional significance is only now becoming clear in relation to cell physiology and …

Neuroinflammation leads to neuronal stress responses that contribute to neuronal
dysfunction and loss. However, treatments that stabilize neurons and prevent their …

The integrity of mitochondrial function is fundamental to cell life. It follows that disturbances
of mitochondrial function will lead to disruption of cell function, expressed as disease or …

Ischemia is a major cause of brain damage, and patient management is complicated by the
paradoxical injury that results from reoxygenation. We have now explored the generation of …

β-Amyloid (βA) peptide is strongly implicated in the neurodegeneration underlying
Alzheimer's disease, but the mechanisms of neurotoxicity remain controversial. This study …

Active oxygen species (AOS) generated in response to stimuli and during development can
function as signalling molecules in eukaryotes, leading to specific downstream responses …

Dietary protocols that increase serum levels of ketones, such as calorie restriction and the
ketogenic diet, offer robust protection against a multitude of acute and chronic neurological …

This article reviews parameters of extrinsic uncoupling of oxidative phosphorylation
(OxPhos) in mitochondria, based on induction of a proton leak across the inner membrane …

Mitochondria play a central role in cell life and cell death. An increasing number of studies
place mitochondrial dysfunction at the heart of disease, most notably in the heart and the …