Interaction scaffolds that selectively recognize disordered protein strongly shape protein
interactomes. An important scaffold of this type that contributes to transcription is the TFIIS N …

Eukaryotic transcription is dependent on specific histone modifications. Their recognition by
chromatin readers triggers complex processes relying on the coordinated association of …

The transcriptional co-activator lens epithelium-derived growth factor/p75 (LEDGF/p75)
plays an important role in the biology of the cell and in several human diseases, including …

The physiological quantum of stress-inducible transcriptional protein, Lens Epithelium-
Derived Growth Factor (LEDGF), is vital for the maintenance of cellular physiology. Erratic …

Chemical cross-linking mass spectrometry has become a popular tool in structural biology.
Although several algorithms exist that efficiently analyze data-dependent mass …

Methyl-CpG-binding protein 2 (MeCP2) is a ubiquitously expressed nuclear protein that is
involved in transcriptional regulation and chromatin remodeling. MeCP2 exists in two …

Proteiny intermediálních filament vytvářejí dynamickou síť cytoskeletálních vláken, která díky
svým elastickým vlastnostem výrazně přispívá k odolnosti buněk a tkání vůči mechanickému …

Mixed lineage leukemia-rearranged (MLL-r) leukemia is a genetically distinct subtype of
leukemia characterized by chromosomal translocations in the MLL1 gene KMT2A and …