Mechanical stress from haemodynamic perturbations or interventional manipulation of
epicardial coronary atherosclerotic plaques with inflammatory destabilization can release …

were identified at relatively high frequency (compared with control subjects or patients with
effort angina) in the peripheral blood. 14 Using an experimental canine model, Eguchi et …

We isolated a cDNA encoding a functional human thrombin receptor by direct expression
cloning in Xenopus oocytes. mRNA encoding this receptor was detected in human platelets …

INCE PLATELETS were first identified in 1881,'there S has been continuous and recently
accelerating progress in our basic understanding of platelet f~ nction.'.~ Despite this great …

The oxidative status of cells is determined by the balance between pro-oxidants and
antioxidants. Pro-oxidants, referred to as reactive oxygen species (ROS), are classified into …

A hypothermia-induced hemorrhagic diathesis is associated with cardiopulmonary bypass,
major surgery, and multiple trauma, but its pathophysiological basis is not well understood …

Platelet function in whole blood can be comprehensively evaluated by flow cytometry. Flow
cytometry can be used to measure platelet reactivity, circulating activated platelets, platelet …

BACKGROUND It has been hypothesized that platelets are activated, or made more
activatible, by strenuous exercise and that these changes may play a role in the genesis of …

The use of cardiopulmonary bypass (CPB) during cardiac surgery is associated with a
hemostatic defect, the hallmark of which is a markedly prolonged bleeding time. However …

The human platelet thrombin receptor is activated when thrombin cleaves its receptor's
amino-terminal extension to reveal a new amino terminus that functions as a tethered …