The annual number of cancer deaths continues increasing every day; thus, it is urgent to
search for and find active, selective, and efficient anticancer drugs as soon as possible …

The aim of this review was to discuss an overview of type 2 diabetes; biology of PTP1B; role
of PTP1B in metabolic disorders; and recent updates in the development of PTP1B inhibitors …

Prenylated flavonoids are a special kind of flavonoid derivative possessing one or more
prenyl groups in the parent nucleus of the flavonoid. The presence of the prenyl side chain …

Background: Diabetes Mellitus (DM), is a metabolic disorder characterized by high blood
glucose levels. The main types of diabetes mellitus are Diabetes mellitus type I, Diabetes …

Background Prenylated phenolics, a type of important bioactive compounds, present with
prenyl group on the phenolic skeleton. Prenylated flavonoids, stilbenoids, courmarins and …

Cudrania tricuspidata is a perennial plant of the family Moraceae with numerous medicinal
and nutritional applications. It has been widely used in East Asia as an important traditional …

Background: There has been growing interest in the development of highly potent and
selective protein tyrosine phosphatase (PTP1B) inhibitors for the past 2-3 decades. Though …

Abstract Type 2 diabetes (T2D) is an expanding global health problem, resulting from
defects in insulin secretion and/or insulin resistance. In the past few years, both protein …

Since PTP1B enzyme was discovered in 1988, it has captured the research community's
attention. This landmark discovery has stimulated numerous research studies on a variety of …

Leptin is mainly secreted by white adipose tissue and regulates energy homeostasis by
inhibiting food intake and stimulating energy expenditure through its action in neuronal …