Th17 and Treg lymphocytes in obesity and Type 2 diabetic patients

M Wang, F Chen, J Wang, Z Zeng, Q Yang, S Shao - Clinical Immunology, 2018 - Elsevier
Assumption that the pathogenesis of obesity-associated type 2 diabetes (T2DM)
encompasses inflammation and autoimmune aspects is increasingly recognized. In the state …

Impacts of high fat diet on ocular outcomes in rodent models of visual disease

DA Clarkson-Townsend, AJ Douglass, A Singh… - Experimental eye …, 2021 - Elsevier
High fat diets (HFD) have been utilized in rodent models of visual disease for over 50 years
to model the effects of lipids, metabolic dysfunction, and diet-induced obesity on vision and …

High-fat diet induces inflammation of meibomian gland

J Bu, M Zhang, Y Wu, N Jiang, Y Guo… - … & Visual Science, 2021 - iovs.arvojournals.org
Purpose: To determine if a high-fat diet (HFD) induces meibomian gland (MG) inflammation
in mice. Methods: Male C57BL/6J mice were fed a standard diet (SD), HFD, or HFD …

Impact of natural curcumin on the progression of experimental periodontitis in diabetic rats

SP Pimentel, MZ Casati, FV Ribeiro… - Journal of …, 2020 - Wiley Online Library
Objective To evaluate the role of natural curcumin (CURC) on experimental periodontitis
(EP) in animals with diabetes mellitus (DM). Material and Methods One hundred rats were …

Local and systemic gene expression levels of IL-10, IL-17 and TGF-β in active ocular toxoplasmosis in humans

A Raouf-Rahmati, AR Ansar, SA Rezaee, SM Hosseini… - Cytokine, 2021 - Elsevier
Background To compare mRNA expression of interleukin 10 (IL-10), interleukin 17 (IL-17)
and Transforming Growth Factor-β (TGF-β) in aqueous humor (AH) and peripheral blood …

AdipoRon negatively regulates proliferation and migration of ARPE-19 human retinal pigment epithelial cells

M Mallardo, C Costagliola, E Nigro, A Daniele - Peptides, 2021 - Elsevier
Adiponectin is an adipokine playing important roles in metabolic, inflammatory and
proliferative processes. At the time of surgery for rhegmatogenous retinal detachment, an …

[HTML][HTML] The effects of Bushen Yiqi Huoxue prescription and its disassembled prescriptions on a diabetic retinopathy model in Sprague Dawley rats

M Xie, L Deng, Y Yu, X Xie, M Zhang - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Background Diabetic retinopathy (DR) is one of the most serious complications in the late
stages of diabetes, with a complex mechanism. As a complication affecting local lesions, few …

[HTML][HTML] Impact of age on host responses to diet-induced obesity: development of joint damage and metabolic set points

KH Collins, GZ MacDonald, DA Hart… - Journal of Sport and …, 2020 - Elsevier
Background Osteoarthritis is one of the leading causes of pain and disability worldwide, and
a large percentage of patients with osteoarthritis are individuals who are also obese. In …

Immunological considerations for retinal stem cell therapy

J Kramer, KR Chirco, DA Lamba - Pluripotent Stem Cells in Eye Disease …, 2019 - Springer
There is an increasing effort toward generating replacement cells for neuronal application
due to the nonregenerative nature of these tissues. While much progress has been made …

[HTML][HTML] Light environment influences developmental programming of the metabolic and visual systems in mice

DA Clarkson-Townsend, KL Bales… - … & Visual Science, 2021 - jov.arvojournals.org
Purpose: Light is a salient cue that can influence neurodevelopment and the immune
system. Light exposure out of sync with the endogenous clock causes circadian disruption …