Towards an understanding of the role of Clostridium perfringens toxins in human and animal disease

FA Uzal, JC Freedman, A Shrestha, JR Theoret… - Future …, 2014 - Future Medicine
Clostridium perfringens uses its arsenal of> 16 toxins to cause histotoxic and intestinal
infections in humans and animals. It has been unclear why this bacterium produces so many …

[HTML][HTML] An approach to alternative strategies to control avian coccidiosis and necrotic enteritis

P Adhikari, A Kiess, R Adhikari, R Jha - Journal of applied poultry research, 2020 - Elsevier
Consumer demands for chickens raised without the use of antibiotics, legislative restrictions,
and trade opportunities have encouraged many integrators within the poultry industry to …

Nanoparticle-detained toxins for safe and effective vaccination

CMJ Hu, RH Fang, BT Luk, L Zhang - Nature nanotechnology, 2013 - nature.com
Toxoid vaccines—vaccines based on inactivated bacterial toxins—are routinely used to
promote antitoxin immunity for the treatment and prevention of bacterial infections …

Alternatives to antibiotics to prevent necrotic enteritis in broiler chickens: a microbiologist's perspective

DL Caly, R D'Inca, E Auclair, D Drider - Frontiers in microbiology, 2015 - frontiersin.org
Since the 2006 European ban on the use of antibiotics as growth promoters in animal feed,
numerous studies have been published describing alternative strategies to prevent diseases …

Avian Pathogenic Escherichia coli and Clostridium perfringens: Challenges in No Antibiotics Ever Broiler Production and Potential Solutions

CA Fancher, L Zhang, AS Kiess, PA Adhikari, TTN Dinh… - Microorganisms, 2020 - mdpi.com
United States is the largest producer and the second largest exporter of broiler meat in the
world. In the US, broiler production is largely converting to antibiotic-free programs which …

Toxin plasmids of Clostridium perfringens

J Li, V Adams, TL Bannam, K Miyamoto… - Microbiology and …, 2013 - Am Soc Microbiol
In both humans and animals, Clostridium perfringens is an important cause of histotoxic
infections and diseases originating in the intestines, such as enteritis and enterotoxemia …

[HTML][HTML] Towards the control of necrotic enteritis in broiler chickens with in-feed antibiotics phasing-out worldwide

SA M'Sadeq, S Wu, RA Swick, M Choct - Animal Nutrition, 2015 - Elsevier
Poultry production has undergone a substantial increase compared to the livestock
industries since 1970. However, the industry worldwide is now facing challenges with the …

Necrotic enteritis in chickens: A review of pathogenesis, immune responses and prevention, focusing on probiotics and vaccination

M Alizadeh, B Shojadoost, N Boodhoo… - Animal Health …, 2021 - cambridge.org
Necrotic enteritis (NE), caused by Clostridium perfringens (CP), is one of the most common
of poultry diseases, causing huge economic losses to the poultry industry. This review …

Engineered nanoparticles mimicking cell membranes for toxin neutralization

RH Fang, BT Luk, CMJ Hu, L Zhang - Advanced drug delivery reviews, 2015 - Elsevier
Protein toxins secreted from pathogenic bacteria and venomous animals rely on multiple
mechanisms to overcome the cell membrane barrier to inflict their virulence effect. A …

[HTML][HTML] Hyperimmune egg yolk antibodies developed against Clostridium perfringens antigens protect against necrotic enteritis

D Goo, UD Gadde, WK Kim, CG Gay, EW Porta… - Poultry Science, 2023 - Elsevier
Necrotic enteritis (NE) is a widespread infectious disease caused by Clostridium perfringens
that inflicts major economic losses on the global poultry industry. Due to regulations on …