Drug-Induced Nephrotoxicity: Clinical Impact and Preclinical in Vitro Models

HY Tiong, P Huang, S Xiong, Y Li… - Molecular …, 2014 - ACS Publications
The kidney is a major target for drug-induced toxicity. Drug-induced nephrotoxicity remains a
major problem in the clinical setting, where the use of nephrotoxic drugs is often …

Advances in understanding and treating diabetic kidney disease: focus on tubulointerstitial inflammation mechanisms

C Xu, X Ha, S Yang, X Tian, H Jiang - Frontiers in Endocrinology, 2023 - frontiersin.org
Diabetic kidney disease (DKD) is a serious complication of diabetes that can lead to end-
stage kidney disease. Despite its significant impact, most research has concentrated on the …

The most promising biomarkers of allogeneic kidney transplant rejection

K Rogulska, I Wojciechowska-Koszko… - Journal of …, 2022 - Wiley Online Library
Clinical transplantology is a constantly evolving field of medicine. Kidney transplantation has
become standard clinical practice, and it has a significant impact on reducing mortality and …

Tumour stroma‐derived lipocalin‐2 promotes breast cancer metastasis

B Ören, J Urosevic, C Mertens, J Mora… - The Journal of …, 2016 - Wiley Online Library
Tumour cell‐secreted factors skew infiltrating immune cells towards a tumour‐supporting
phenotype, expressing pro‐tumourigenic mediators. However, the influence of lipocalin‐2 …

Revisiting neutrophil gelatinase-associated lipocalin (NGAL) in cancer: saint or sinner?

B Bauvois, SA Susin - Cancers, 2018 - mdpi.com
Human neutrophil gelatinase-associated lipocalin (NGAL) is a glycoprotein present in a
wide variety of tissues and cell types. NGAL exists as a 25 kDa monomer, a 46 kDa …

Lipocalin-2 and iron trafficking in the tumor microenvironment

M Jung, C Mertens, R Bauer, C Rehwald… - Pharmacological …, 2017 - Elsevier
Iron is an essential element for virtually all organisms. It facilitates cell proliferation and
growth but also contributes to major hallmarks of cancer such as tumor initiation, growth, and …

Novel biomarkers of acute kidney injury in chronic liver disease: Where do we stand after a decade of research?

RV Yewale, BS Ramakrishna - Hepatology Research, 2023 - Wiley Online Library
Acute kidney injury (AKI) is a frequently encountered complication in decompensated
chronic liver disease (CLD) with an estimated prevalence of 20%–50% among hospitalized …

[HTML][HTML] Subclinical aki and clinical outcomes in elderly patients undergoing cardiac surgery: Diagnostic utility of ngal versus standard creatinine increase criteria

M Marcello, GM Virzì, MJ Muciño-Bermejo… - Cardiorenal …, 2022 - karger.com
Background: Acute kidney injury (AKI) is a common and serious postoperative complication
in patients undergoing cardiac surgery and its incidence is particularly high among elderly …

Urine neutrophil gelatinase‐associated lipocalin to diagnose and characterize acute kidney injury in dogs

E Monari, R Troìa, L Magna, M Gruarin… - Journal of veterinary …, 2020 - Wiley Online Library
Background Urine neutrophil gelatinase‐associated lipocalin (NGAL) is a promising
biomarker of acute kidney injury (AKI) in dogs. Objectives To evaluate the utility of urinary …

Urinary versus plasma neutrophil gelatinase-associated lipocalin (NGAL) as a predictor of mortality for acute kidney injury in intensive care unit patients

A Mahmoodpoor, H Hamishehkar, V Fattahi… - Journal of clinical …, 2018 - Elsevier
Objective To examine urinary and plasma neutrophil gelatinase-associated lipocalin (NGAL)
levels in predicting ICU mortality. Design Prospective observational. Setting University …