The β2-integrin receptor family has a broad spectrum of physiological functions ranging from
leukocyte adhesion, cell migration, activation, and communication to the phagocytic uptake …

Platelets are essential for the formation of a haemostatic plug to prevent bleeding, while
neutrophils are the guardians of our immune defences against invading pathogens. The …

Streptococcus sanguinis is a common cause of infective endocarditis (IE). Efforts by
research groups are aimed at identifying and characterizing virulence factors that contribute …

Lupus nephritis (LN) develops in more than a third of all systemic lupus erythematosus
(SLE) patients and is the strongest predictor of morbidity and mortality. Increased circulating …

Abstract Complement receptor 3 (CR3, also known as Mac-1, integrin α M β 2, or
CD11b/CD18) is expressed on a subset of myeloid and certain activated lymphoid cells …

Although anti-citrullinated protein autoantibodies (ACPAs) are a hallmark serological feature
of rheumatoid arthritis (RA), the mechanisms and cellular sources behind the generation of …

Recent studies have showed that thrombosis is closely related to leucocytes involved in
immunity. Interfering with the binding of leukocyte integrin Mac-1 and platelet GPIbα can …

The integrin receptor α M β 2 mediates phagocytosis of complement-opsonized objects,
adhesion to the extracellular matrix, and transendothelial migration of leukocytes. However …

The pyGROMODS, an easy-to-use cross-platform python-based package, with a graphical
user interface, for the generation of molecular dynamic (MD) input files and running MD …

The integrin Mac-1 (α M β 2, CD11b/CD18, CR3) is an adhesion receptor expressed on
macrophages and neutrophils. Mac-1 is also a promiscuous integrin that binds a diverse set …