Neuroimaging and fluid biomarkers in Parkinson's disease in an era of targeted interventions
A Zarkali, GEC Thomas, H Zetterberg… - Nature …, 2024 - nature.com
A major challenge in Parkinson's disease is the variability in symptoms and rates of
progression, underpinned by heterogeneity of pathological processes. Biomarkers are …
progression, underpinned by heterogeneity of pathological processes. Biomarkers are …
Imaging the limbic system in Parkinson's disease—a review of limbic pathology and clinical symptoms
M Banwinkler, H Theis, S Prange, T van Eimeren - Brain sciences, 2022 - mdpi.com
The limbic system describes a complex of brain structures central for memory, learning, as
well as goal directed and emotional behavior. In addition to pathological studies, recent …
well as goal directed and emotional behavior. In addition to pathological studies, recent …
Mapping neurotransmitter systems to the structural and functional organization of the human neocortex
Neurotransmitter receptors support the propagation of signals in the human brain. How
receptor systems are situated within macro-scale neuroanatomy and how they shape …
receptor systems are situated within macro-scale neuroanatomy and how they shape …
Local molecular and global connectomic contributions to cross-disorder cortical abnormalities
Numerous brain disorders demonstrate structural brain abnormalities, which are thought to
arise from molecular perturbations or connectome miswiring. The unique and shared …
arise from molecular perturbations or connectome miswiring. The unique and shared …
Integrating multimodal and multiscale connectivity blueprints of the human cerebral cortex in health and disease
The brain is composed of disparate neural populations that communicate and interact with
one another. Although fiber bundles, similarities in molecular architecture, and synchronized …
one another. Although fiber bundles, similarities in molecular architecture, and synchronized …
In vivo mapping of pharmacologically induced functional reorganization onto the human brain's neurotransmitter landscape
To understand how pharmacological interventions can exert their powerful effects on brain
function, we need to understand how they engage the brain's rich neurotransmitter …
function, we need to understand how they engage the brain's rich neurotransmitter …
Contributions of network structure, chemoarchitecture and diagnostic categories to transitions between cognitive topographies
The mechanisms linking the brain's network structure to cognitively relevant activation
patterns remain largely unknown. Here, by leveraging principles of network control, we show …
patterns remain largely unknown. Here, by leveraging principles of network control, we show …
Structural brain changes in patients with persistent headache after COVID-19 resolution
Headache is among the most frequently reported symptoms after resolution of COVID-19.
We assessed structural brain changes using T1-and diffusion-weighted MRI processed data …
We assessed structural brain changes using T1-and diffusion-weighted MRI processed data …
[HTML][HTML] Explainable classification of Parkinson's disease using deep learning trained on a large multi-center database of T1-weighted MRI datasets
Introduction Parkinson's disease (PD) is a severe neurodegenerative disease that affects
millions of people. Early diagnosis is important to facilitate prompt interventions to slow …
millions of people. Early diagnosis is important to facilitate prompt interventions to slow …
Neurofilament light chain is increased in the parahippocampal cortex and associates with pathological hallmarks in Parkinson's disease dementia
I Frigerio, MA Laansma, CP Lin, EJM Hermans… - Translational …, 2023 - Springer
Background Increased neurofilament levels in biofluids are commonly used as a proxy for
neurodegeneration in several neurodegenerative disorders. In this study, we aimed to …
neurodegeneration in several neurodegenerative disorders. In this study, we aimed to …