The expression of mitochondrial genes is regulated in response to the metabolic needs of
different cell types, but the basic mechanisms underlying this process are still poorly …

Mitochondria are cellular organelles responsible for generation of chemical energy in the
process called oxidative phosphorylation. They originate from a bacterial ancestor and …

Cardiovascular disease (CVD) is the leading cause of disease-related death worldwide and
a significant obstacle to improving patients' health and lives. Mitochondria are core …

Mitochondria are the major source of ATP in the cell. Five multi-subunit complexes in the
inner membrane of the organelle are involved in the oxidative phosphorylation required for …

Inherited disorders of oxidative phosphorylation cause the clinically and genetically
heterogeneous diseases known as mitochondrial energy generation disorders, or …

Mitochondria are eukaryotic organelles that generate most of the energy in the cell by
oxidative phosphorylation (OXPHOS). Each mitochondrion contains multiple copies of a …

The complexity of the functional proteome extends considerably beyond the coding genome,
resulting in millions of proteoforms. Investigation of proteoforms and their functional roles is …

Human mitochondrial transcripts contain messenger and ribosomal RNAs flanked by
transfer RNAs (tRNAs), which are excised by mitochondrial RNase (mtRNase) P and Z to …

Perturbation of mitochondrial DNA (mtDNA) gene expression can lead to human
pathologies. Therefore, a greater appreciation of the basic mechanisms of mitochondrial …

Thermosensitive genic male-sterile (TGMS) lines, which are male-sterile at restrictive (high)
temperatures but male-fertile at permissive (low) temperatures, have been widely used in …