Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

NAD+ was discovered during yeast fermentation, and since its discovery, its important roles
in redox metabolism, aging, and longevity, the immune system and DNA repair have been …

Oxidative stress and inflammation interact in the development of diabetic atherosclerosis.
Intracellular hyperglycemia promotes production of mitochondrial reactive oxygen species …

Research on the biology of NAD+ has been gaining momentum, providing many critical
insights into the pathogenesis of age-associated functional decline and diseases. In …

Persistent, unresolved inflammation in adipose tissue is a major contributor to obesity-
associated metabolic complications. However, the molecular links between lipid-overloaded …

The clinical correlations linking diabetes mellitus with accelerated atherosclerosis,
cardiomyopathy, and increased post-myocardial infarction fatality rates are increasingly …

Nicotinamide phosphoribosyltransferase (NAMPT) is a regulator of the intracellular
nicotinamide adenine dinucleotide (NAD) pool. NAD is an essential coenzyme involved in …

Lines of evidence from several studies have shown that increases in life expectancy are now
accompanied by increased disability rate. The expanded lifespan of the aging population …

Background Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disease ranging from
simple hepatic steatosis (NAFL) to non-alcoholic steatohepatitis (NASH) which may …

Nicotinamide adenine dinucleotide (NAD) is an important co-factor involved in numerous
physiological processes, including metabolism, post-translational protein modification, and …