The cloning of mammals from differentiated donor cells has refuted the old dogma that
development is an irreversible process. It has demonstrated that the oocyte can …

Fertile offspring from somatic cell nuclear transfer (SCNT) is the goal of most cloning
laboratories. For this process to be successful, a number of events must occur correctly. First …

Derivation of embryonic stem (ES) cells genetically identical to a patient by somatic cell
nuclear transfer (SCNT) holds the potential to cure or alleviate the symptoms of many …

Patient-specific, immune-matched human embryonic stem cells (hESCs) are anticipated to
be of great biomedical importance for studies of disease and development and to advance …

Nuclear transfer stem cells hold considerable promise in the field of regenerative medicine
and cell-based drug discovery. In this study, a total of 29 oocytes were obtained from three …

Human embryonic stem cells are pluripotent entities, theoretically capable of generating a
whole-body spectrum of distinct cell types. However, differentiation of these cells has been …

The successful establishment of human embryonic stem cell (hESC) lines has inaugurated a
new era in regenerative medicine by facilitating the transplantation of differentiated ESCs to …

This paper describes the derivation of a blastocyst following heterologous nuclear transfer
(NT) into a human oocyte. It also demonstrates that a major obstacle to continuing research …

Synthetic and natural estrogens as well as progestins modulate neuronal development and
activity. Neurons and glia are endowed with high-affinity steroid receptors. Besides …

BACKGROUND Somatic cell nuclear transfer (SCNT) requires cytoplast-mediated
reprogramming of the donor nucleus. Cytoplast factors such as maturation promoting factor …