The role of the dopamine (DA) system in brain reward mechanisms and the development of
substance abuse has been well established. We review earlier animal and human studies …

Alcoholism is associated with brain damage and impaired cognitive functioning. The relative
contributions of different etiological factors, such as alcohol, thiamine deficiency and age …

Chronic alcoholism is associated with impaired cognitive functioning. Over 75% of autopsied
chronic alcoholics have significant brain damage and over 50% of detoxified alcoholics …

Alterations of brain structures have been seen in patients suffering from drug abuse or
mental disorders like schizophrenia. Similar changes in volume of brain structures have …

Drug addiction is a compulsive behavioral abnormality. In spite of pharmacological
treatments and psychosocial support to reduce or eliminate drug intake, addiction tends to …

The adverse effects of acute and chronic ethanol exposure on cerebellar functions have
been acknowledged for decades, in terms of impaired control of movement and balance. In …

There is evidence that chronic ethanol treatment (CET) disrupts the biological rhythms of
various brain functions and behaviors. Because the suprachiasmatic nucleus (SCN) is …

We have examined if long-term (13 months) alcohol consumption and the same treatment
followed by a 6-week withdrawal period cause different neuropathological changes in rats …

Neuroinflammation has been implicated in the pathogenesis of several disorders. Activation
of microglia leads to the release of pro-inflammatory mediators and microglial-mediated …

Abstract We used (+)[11C] dihydrotetrabenazine, a new ligand for the type 2 vesicular
monoamine transporter, with positron emission tomography to study striatal monoaminergic …