The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9
single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta …

Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the
transcriptional control of lipid metabolism. Transcriptional activity of LXRs is induced in …

An ideal animal model of atherosclerosis resembles human anatomy and pathophysiology
and has the potential to be used in medical and pharmaceutical research to obtain results …

The remarkable plasticity and plethora of biological functions performed by macrophages
have enticed scientists to study these cells in relation to atherosclerosis for> 50 years, and …

Animal studies are a foundation for defining mechanisms of atherosclerosis and potential
targets of drugs to prevent lesion development or reverse the disease. In the current …

Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD).
Risk of cardiovascular events depends on cumulative lifetime exposure to low-density …

The inflammatory nature of atherosclerosis is well established but the agent (s) that incite
inflammation in the artery wall remain largely unknown. Germ-free animals are susceptible …

The etiology of aortic aneurysms is poorly understood, but it is associated with
atherosclerosis, hypercholesterolemia, and abnormal transforming growth factor β (TGF-β) …

In recent years, type 2 diabetes mellitus has evolved as a rapidly increasing epidemic that
parallels the increased prevalence of obesity and which markedly increases the risk of …

Atherosclerotic cardiovascular disease is a major cause of death among humans. Animal
models have shown that cholesterol and inflammation are causatively involved in the …