This guideline is the second European Crohn's and Colitis Organisation [ECCO] evidence-
based consensus on inflammatory bowel disease [IBD] and malignancy, and is an update …

Rheumatoid arthritis is a systemic autoimmune disorder involved in persistent synovial
inflammation. Berberine is a nature-derived alkaloid compound with multiple …

Prurigo nodularis is a chronic inflammatory skin disease consisting of severely pruritic
nodules that can be very debilitating for patients. The basis of this skin condition is …

Background Methotrexate (MTX) use has been suspected of increasing the risk of skin
cancer. The aim of this investigation was to examine the association between the use of …

Importance Low-dose methotrexate is used to treat rheumatoid arthritis and psoriasis. Due to
its kidney elimination, better evidence is needed to inform its safety in adults with chronic …

Background Low-dose methotrexate (LD-MTX) is contraindicated in advanced CKD, but
kidney safety in normal kidney function or mild-to-moderate CKD is less clear. Methods We …

Importance Methotrexate is widely used for the treatment of inflammatory disorders,
including rheumatoid arthritis. Studies suggest that methotrexate may be associated with an …

Patients with inflammatory bowel disease (IBD) have an increased risk of cancer secondary
to chronic inflammation and long-term use of immunosuppressive therapy. With the aging …

Simple Summary Psoriasis is an inflammatory disease associated with important
comorbidities that shape a specific clinical frame. Concerns have been expressed in recent …

Nucleotides perform important metabolic functions, carrying energy and feeding nucleic acid
synthesis. Here, we use isotope tracing-mass spectrometry to quantitate contributions to …