Antibiotics and antibiotic resistance genes (ARGs) are prevalent in estuarine and coastal
environments due to substantial terrestrial input, aquaculture effluent, and sewage …

The widespread use of antibiotics results in the generation of antibiotic concentration
gradients in humans, livestock and the environment. Thus, bacteria are frequently exposed …

The publication of crystal structures of the 50S and 30S ribosomal subunits and the intact
70S ribosome is revolutionizing our understanding of protein synthesis. This review is an …

Crystal structures of the 30 S ribosomal subunit in complex with messenger RNA and
cognate transfer RNA in the A site, both in the presence and absence of the antibiotic …

Since the discovery of the first aminoglycoside antibiotic, streptomycin (Str), in 1944, the
mechanism of action of this group has been studied more extensively, and in more …

Drug resistance in tuberculosis (TB) is a particular problem because the lengthy therapy of
at least 6 months makes patient compliance very difficult, which frequently creates drug …

Termination of protein synthesis is not 100% efficient. A number of natural mechanisms that
suppress translation termination exist. One of them is STOP codon readthrough, the process …

Aneuploidy causes a proliferative disadvantage in all normal cells analyzed to date, yet this
condition is associated with a disease characterized by unabated proliferative potential …

▪ Abstract The underlying basis for the accuracy of protein synthesis has been the subject of
over four decades of investigation. Recent biochemical and structural data make it possible …

A structural and mechanistic explanation for the selection of tRNAs by the ribosome has
been elusive. Here, we report crystal structures of the 30S ribosomal subunit with codon and …