A systematic review on the kappa opioid receptor and its ligands: New directions for the treatment of pain, anxiety, depression, and drug abuse

MIH Khan, BJ Sawyer, NS Akins, HV Le - European Journal of Medicinal …, 2022 - Elsevier
Kappa opioid receptor (KOR) is a member of the opioid receptor system, the G protein-
coupled receptors that are expressed throughout the peripheral and central nervous …

Molecular mechanisms of inverse agonism via κ-opioid receptor–G protein complexes

AS Tyson, S Khan, Z Motiwala, GW Han… - Nature Chemical …, 2025 - nature.com
Opioid receptors, a subfamily of G protein-coupled receptors (GPCRs), are key therapeutic
targets. In the canonical GPCR activation model, agonist binding is required for receptor–G …

[HTML][HTML] Therapeutic Potential of Salvinorin A and Its Analogues in Various Neurological Disorders

J Cichon, R Liu, HV Le - Translational perioperative and pain …, 2022 - ncbi.nlm.nih.gov
While the hallucinogenic plant Salvia divinorum has been safely consumed by humans for
centuries for religious or recreational purposes without long-term side effects, its active …

Endogenous opiates and behavior: 2023

RJ Bodnar - Peptides, 2024 - Elsevier
This paper is the forty-sixth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Studien zur Totalsynthese des trans-neo-Clerodans Salvinorin A

M Halang - 2023 - tobias-lib.ub.uni-tuebingen.de
Salvinorin A ist ein psychotroper Naturstoff, welcher 1982 erstmals aus den getrockneten
Blättern des Azteken-Salbeis (Salvia divinorum) extrahiert wurde. Er besitzt eine geringe …