Transcriptional and epigenetic regulation of autophagy in aging
Macroautophagy is a major intracellular degradation process recognized as playing a
central role in cell survival and longevity. This multistep process is extensively regulated at …
central role in cell survival and longevity. This multistep process is extensively regulated at …
Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration
K Kaarniranta, D Sinha, J Blasiak, A Kauppinen… - Autophagy, 2013 - Taylor & Francis
Age-related macular degeneration (AMD) is a complex, degenerative and progressive eye
disease that usually does not lead to complete blindness, but can result in severe loss of …
disease that usually does not lead to complete blindness, but can result in severe loss of …
Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway
V Bouché, AP Espinosa, L Leone, M Sardiello… - Autophagy, 2016 - Taylor & Francis
An evolutionarily conserved gene network regulates the expression of genes involved in
lysosome biogenesis, autophagy, and lipid metabolism. In mammals, TFEB and other …
lysosome biogenesis, autophagy, and lipid metabolism. In mammals, TFEB and other …
Quantitative measurement of the histological features of alpha-1 antitrypsin deficiency-associated liver disease in biopsy specimens
Background Pathological mutations in Alpha-1 Antitrypsin (AAT) protein cause retention of
toxic polymers in the hepatocyte endoplasmic reticulum. The risk for cirrhosis in AAT …
toxic polymers in the hepatocyte endoplasmic reticulum. The risk for cirrhosis in AAT …
Reduction of WDR81 impairs autophagic clearance of aggregated proteins and cell viability in neurodegenerative phenotypes
X Liu, L Yin, T Li, L Lin, J Zhang, Y Li - PLoS genetics, 2021 - journals.plos.org
Neurodegenerative diseases are characterized by neuron loss and accumulation of
undegraded protein aggregates. These phenotypes are partially due to defective protein …
undegraded protein aggregates. These phenotypes are partially due to defective protein …
Autophagy in ocular pathophysiology
SK Mitter, ME Boulton - Autophagy in Current Trends in Cellular …, 2016 - books.google.com
Autophagy is an evolutionarily conserved intracellular recycling pathway that is
indispensable for cellular quality control. Dysfunctional autophagy has been associated with …
indispensable for cellular quality control. Dysfunctional autophagy has been associated with …
Autophagy and gene therapy combine in the treatment of liver disease
DA Thompson, DJ Klionsky - Autophagy, 2013 - Taylor & Francis
Molecular biology holds the promise not only of increasing our understanding of basic cell
biology, but also of advancing our ability to design targeted therapeutic methods for treating …
biology, but also of advancing our ability to design targeted therapeutic methods for treating …