The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …

Neuroinflammation has been identified as a causative factor of multiple neurological
diseases. The nucleotide-binding oligomerization domain-, leucine-rich repeat-and pyrin …

Inflammasomes are macromolecular platforms formed in response to damage-associated
molecular patterns (DAMPs) and pathogen-associated molecular patterns, whose formation …

Background: Skin wound healing is a challenging problem, especially in aging or diabetic
patients, which becomes more difficult to heal, and easily results in considerable public …

In the literature, burns are understood as traumatic events accompanied by increased
morbidity and mortality among affected patients. Their characteristic feature is the formation …

Intracerebral hemorrhage (ICH) is the most fatal subtype of stroke; there is still a lack of
effective treatment. Microglia are a major component of the innate immune system, and they …

Nucleotide-binding oligomerization domain NOD-like receptors (NLRs) are conserved
cytosolic pattern recognition receptors (PRRs) that track the intracellular milieu for the …

Burn wound conversion refers to the phenomenon whereby superficial burns that appear to
retain the ability to spontaneously heal, convert later into deeper wounds in need of …

Inflammatory bowel disease (IBD) has been reported to be associated with NLRP3
inflammasome activation. Therefore inhibiting inflammasome activation could be a new …

Modulating the immune system to treat diseases, including myeloid malignancies, has
resulted in the development of a multitude of novel therapeutics in recent years …