Computational modeling of realistic cell membranes
Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …
Emerging diversity in lipid–protein interactions
Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …
membrane environment for proteins to being embedded in to detailed roles in complicated …
Coarse-grained protein models and their applications
The traditional computational modeling of protein structure, dynamics, and interactions
remains difficult for many protein systems. It is mostly due to the size of protein …
remains difficult for many protein systems. It is mostly due to the size of protein …
Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
Characterization of lipid–protein interactions and lipid-mediated modulation of membrane protein function through molecular simulation
The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …
cell, where key processes such as selective transport of material and exchange of …
Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling
Cholesterol is necessary for the function of many G-protein coupled receptors (GPCRs). We
find that cholesterol is not just necessary but also sufficient to activate signaling by the …
find that cholesterol is not just necessary but also sufficient to activate signaling by the …
Biological membrane organization and cellular signaling
To execute their many vital functions, cell membranes are highly organized. Here, we review
how membrane structure shapes signal transduction across membranes. Recent …
how membrane structure shapes signal transduction across membranes. Recent …
Excessive aggregation of membrane proteins in the Martini model
M Javanainen, H Martinez-Seara, I Vattulainen - PloS one, 2017 - journals.plos.org
The coarse-grained Martini model is employed extensively to study membrane protein
oligomerization. While this approach is exceptionally promising given its computational …
oligomerization. While this approach is exceptionally promising given its computational …
Interaction of G protein coupled receptors and cholesterol
G Gimpl - Chemistry and physics of lipids, 2016 - Elsevier
G protein coupled receptors (GPCRs) form the largest receptor superfamily in eukaryotic
cells. Owing to their seven transmembrane helices, large parts of these proteins are …
cells. Owing to their seven transmembrane helices, large parts of these proteins are …
Compartmentalized GPCR signaling from intracellular membranes
SE Crilly, MA Puthenveedu - The Journal of Membrane Biology, 2021 - Springer
G protein-coupled receptors (GPCRs) are integral membrane proteins that transduce a wide
array of inputs including light, ions, hormones, and neurotransmitters into intracellular …
array of inputs including light, ions, hormones, and neurotransmitters into intracellular …