Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation

SW Ryter, AMK Choi - Translational Research, 2016 - Elsevier
The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …

Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications

SW Ryter, J Alam, AMK Choi - Physiological reviews, 2006 - journals.physiology.org
The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2),
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …

Nrf2 and heme oxygenase-1 involvement in atherosclerosis related oxidative stress

JA Alonso-Piñeiro, A Gonzalez-Rovira… - Antioxidants, 2021 - mdpi.com
Atherosclerosis remains the underlying process responsible for cardiovascular diseases
and the high mortality rates associated. This chronic inflammatory disease progresses with …

Looking to the horizon: the role of bilirubin in the development and prevention of age-related chronic diseases

KH Wagner, M Wallner, C Mölzer, S Gazzin… - Clinical …, 2015 - portlandpress.com
Bilirubin, the principal tetrapyrrole, bile pigment and catabolite of haem, is an emerging
biomarker of disease resistance, which may be related to several recently documented …

New insights into intracellular locations and functions of heme oxygenase-1

LL Dunn, RG Midwinter, J Ni, HA Hamid… - Antioxidants & redox …, 2014 - liebertpub.com
Abstract Significance: Heme oxygenase-1 (HMOX1) plays a critical role in the protection of
cells, and the inducible enzyme is implicated in a spectrum of human diseases. The …

Gilbert syndrome, UGT1A1* 28 allele, and cardiovascular disease risk: possible protective effects and therapeutic applications of bilirubin

HA Schwertner, L Vítek - Atherosclerosis, 2008 - Elsevier
Serum bilirubin has been shown to be inversely related to cardiovascular disease (CVD) in
both retrospective and prospective studies. Meta-analysis of existing studies has also …

The heme catabolic pathway and its protective effects on oxidative stress‐mediated diseases

L Vítek, HA Schwertner - Advances in clinical chemistry, 2007 - Elsevier
Bilirubin, the principal bile pigment, is the end product of heme catabolism. For many years,
bilirubin was thought to have no physiological function other than that of a waste product of …

Low serum bilirubin level as an independent predictor of stroke incidence: a prospective study in Korean men and women

H Kimm, JE Yun, J Jo, SH Jee - Stroke, 2009 - Am Heart Assoc
Background and Purpose—Bilirubin is not only a waste end-product but also an antioxidant.
Bilirubin is known to be associated with decrease in cardiovascular risk in men, but its …

Serum total bilirubin level, prevalent stroke, and stroke outcomes: NHANES 1999–2004

TS Perlstein, RL Pande, MA Creager, J Weuve… - The American journal of …, 2008 - Elsevier
BACKGROUND: Bilirubin inhibits experimental atherosclerosis, is inversely associated with
carotid plaque burden, and confers neuroprotection in experimental stroke. Clinical data …

Serum total bilirubin level and prevalent lower-extremity peripheral arterial disease: National Health and Nutrition Examination Survey (NHANES) 1999 to 2004

TS Perlstein, RL Pande, JA Beckman… - … , and vascular biology, 2008 - Am Heart Assoc
Background—Bilirubin, with recently recognized antioxidant and antiinflammatory activity,
has emerged as a candidate for atheroprotection. We hypothesized that higher levels of …