It has been shown that lysosomal cysteine proteinases, specially cathepsin B, has been
implicated in a variety of diseases involving tissue remodeling states, such as inflammation …

Cysteine cathepsins are proteases critical in physiopathological processes and show
potential as targets or biomarkers for diseases and medical conditions. The 11 members of …

The 43-kDa glycoprotein of Paracoccidioides brasiliensis is the major diagnostic antigen of
paracoccidioidomycosis, the prevalent systemic mycosis of Latin America. Apart from …

The neutrophil serine proteases (NSPs) elastase, proteinase 3 and cathepsin G are
multifunctional proteases involved in pathogen destruction and the modulation of …

The main feature distinguishing cathepsin B from other cysteine proteases of the papain
family is the presence of a large insertion loop, termed the occluding loop, which occupies …

Quenched fluorescence peptides were used to investigate the substrate specificity
requirements for recombinant wild-type angiotensin I-converting enzyme (ACE) and two full …

Publisher Summary This chapter presents a survey on handles—both standard and
preformed, which have proved their usefulness over the years. The chapter emphasizes on …

Background Micrurus snake bites can cause death by muscle paralysis and respiratory
arrest, few hours after envenomation. The specific treatment for coral snake envenomation is …

Infections caused by Gram-negative bacteria, Escherichia coli and Pseudomonas
aeruginosa foremost among them, constitute a major worldwide health problem …

The major isoform of Trypanosoma cruzi cysteinyl proteinase (cruzipain) has generated Lys-
bradykinin (Lys-BK or kallidin), a proinflammatory peptide, by proteolysis of kininogen. The …